J Rheumatol:ANCA相关性血管炎中动静脉血栓形成的发病率高

2018-11-07 xiangting MedSci原创

AAV患者动静脉血栓形成的发病率高,尤其是诊断后的第一年。

这项研究旨在确定抗中性粒细胞胞浆抗体相关性血管炎(AAV)中动脉血栓事件(ATE)和静脉血栓栓塞(VTE)的发病率。

这是一项回顾性队列研究,分析了2005年至2014年诊断为AAV患者的ATE(冠脉事件或缺血性卒中)和VTE [肺栓塞(PE)或深静脉血栓形成(DVT)]的发病率。

共确定了204名AAV患者。存活患者的中位随访时间为5.8年(范围1-10),代表1088人年(PY)。ATE的发病率为2.67/100PY(冠脉事件为1.56,缺血性卒中为1.10),VTE为1.47/100PY(仅DVT为0.83,伴/不伴DVT的PE为0.64)。在多因素分析中,既往患缺血性心脏病(IHD)和年龄大是ATE的唯一独立预测因子。既往无IHD或卒中的患者中,ATE的发病率仍然升至2.32/100PY(冠脉事件为1.26,缺血性卒中为1.06)。ATE,而不是VTE,是全因死亡率的独立预测因子。确诊AAV后的第一年,ATE和VTE的事件发生率最高,在10年随访期间仍高于人群发病率。与报道的英国人群发病率比较,这些AAV患者冠脉事件发病率高15倍,偶发性卒中高11倍,VTE高20倍。

AAV患者动静脉血栓形成的发病率高,尤其是诊断后的第一年。

原始出处:

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    2019-08-04 fusion
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    2018-11-13 wxl882001

    学习一下

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351936, encodeId=65de3519367a, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 08 09:49:53 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
    2018-11-09 Boyinsh
  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351936, encodeId=65de3519367a, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Nov 08 09:49:53 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
    2018-11-08 Y—xianghai

    学习了长知识

    0

  10. 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    2018-11-08 Y—xianghai

    学习了长知识

    0

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