NEJM:TAVR后念珠菌性心内膜炎-病例报道

2019-01-03 xing.T MedSci原创

经食道超声心动图(如图A所示)证实为人工瓣膜心内膜炎,其显示大量赘生物导致人工瓣膜严重受阻(跨瓣平均压力梯度为52 mmHg;主动脉瓣面积为0.5cm2)。

患者为一名有充血性心力衰竭病史且射血分数为45%的76岁男性,因呼吸急促而到急诊就诊。他在9个月前接受了经导管主动脉瓣置换术(TAVR)。

他的体温为39.0°C,在心脏检查中检测到5级收缩期杂音(伴有可触知的震颤)。胸部X线片显示与肺水肿一致的变化。实验室检查结果值得注意的是白细胞计数为每立方毫米16,000个细胞(参考范围为4000到10000),C反应蛋白水平为120毫克/升(参考范围<5)。




连续六次血培养发现近平滑念珠菌阳性,开始接受抗真菌剂治疗。经食道超声心动图(如图A所示)证实为人工瓣膜心内膜炎,其显示大量赘生物导致人工瓣膜严重受阻(跨瓣平均压力梯度为52 mmHg;主动脉瓣面积为0.5cm2)。

该患者进行外科主动脉瓣置换,观察到赘生物(如图B箭标所示)和原生小叶(如图B箭头所示)。手术部位的伤口感染使术后病程复杂化。患者出院但4周后因肺炎再次入院。在住院2个月后,他死于呼吸系统疾病。

原始出处:

Thierry Carrel, et al.Candida Endocarditis after TAVR.N Engl J Med 2018;https://www.nejm.org/doi/full/10.1056/NEJMicm1809948

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    2019-01-03 明月清辉

    谢谢分享,学习了

    0

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