J Neural Eng:干眼症患者的福音——新型电子装置可有效刺激泪液的分泌

2015-12-14 MedSci MedSci原创

日前,科学家已研制出一种可刺激眼泪分泌的电子装置,这或可为干眼综合征患者的治疗带来新的希望,该研究结果已于12月11日发表于 Journal of Neural Engineering。

日前,科学家已研制出一种可刺激眼泪分泌的电子装置,这或可为干眼综合征患者的治疗带来新的希望,该研究结果已于12月11日发表于 Journal of Neural Engineering。

该电子装置,长16 mm,宽3-4 mm,厚1-2 mm,植入在兔眼的泪腺下。无线控制,可增加了近57% 泪液的分泌量。

“干眼症”——泪液分泌量较少导致角膜和结膜发炎,是一种最常见的眼部疾病。在美国,干眼症影响了5-6%的人口,近500万65岁以上老人患有干眼症。目前还未有有效的治疗方法。

研究人员还发现,传入神经通路(从感觉神经元到大脑的神经通路,激活泪腺分泌的发射弧)提供了一个刺激泪腺分泌泪液的更有效的方式。

研究人员最初的目的是为了刺激泪腺分泌泪液,意外发现刺激传入神经通路则会提供一种更有效且持久的分泌效果。

研究的下一个阶段将是评估改装置刺激产生的泪液的质量、体积、蛋白质和脂质含量。目前该设备正在进行临床试验以获得FDA的批准。

研究人员希望该设备可在明年上市,同时,他们还将继续研究泪液分泌发射的机制,完善该装置,并提高该设备刺激所产生的泪液的质量。

原始出处:

Neural stimulation offers treatment for 'dry eye'.Science Daily, December 11, 2015.

Mark Brinton, Jae Lim Chung, Andrea Kossler, Koung Hoon Kook, Jim Loudin, Manfred Franke, Daniel Palanker. Electronic enhancement of tear secretion. Journal of Neural Engineering, 2016; 13 (1): 016006 DOI: 10.1088/1741-2560/13/1/016006

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    2016-02-08 gwc392
  2. [GetPortalCommentsPageByObjectIdResponse(id=1682225, encodeId=a8e516822252f, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Feb 08 12:08:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48397, encodeId=7e444839ec7, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:57:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081333, encodeId=ecda2081333ff, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sun Nov 20 13:08:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376835, encodeId=be9113e683589, content=<a href='/topic/show?id=391248e4933' target=_blank style='color:#2F92EE;'>#干眼症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48749, encryptionId=391248e4933, topicName=干眼症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=21e5394, createdName=yeaweam, createdTime=Wed Dec 16 04:08:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527307, encodeId=79ec152e30753, content=<a href='/topic/show?id=533248e474a' target=_blank style='color:#2F92EE;'>#干眼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48747, encryptionId=533248e474a, topicName=干眼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11b211837688, createdName=nian.wang1986, createdTime=Wed Dec 16 04:08:00 CST 2015, time=2015-12-16, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

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    2016-11-20 spoonycyy
  4. [GetPortalCommentsPageByObjectIdResponse(id=1682225, encodeId=a8e516822252f, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Feb 08 12:08:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48397, encodeId=7e444839ec7, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:57:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081333, encodeId=ecda2081333ff, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Sun Nov 20 13:08:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376835, encodeId=be9113e683589, content=<a href='/topic/show?id=391248e4933' target=_blank style='color:#2F92EE;'>#干眼症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48749, encryptionId=391248e4933, topicName=干眼症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=21e5394, createdName=yeaweam, createdTime=Wed Dec 16 04:08:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527307, encodeId=79ec152e30753, content=<a href='/topic/show?id=533248e474a' target=_blank style='color:#2F92EE;'>#干眼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48747, encryptionId=533248e474a, topicName=干眼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11b211837688, createdName=nian.wang1986, createdTime=Wed Dec 16 04:08:00 CST 2015, time=2015-12-16, status=1, ipAttribution=)]
    2015-12-16 yeaweam
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