J Rheumatol:骨小梁缺失与中轴型脊柱关节炎疾病活动性的纵向关联

2019-11-26 xiangting MedSci原创

使用TBS评估的axSpA患者骨小梁缺失与ASDAS评分、炎性标志物呈纵向相关。

这项研究旨在探讨骨小梁缺失是否与中轴型脊柱关节炎(axSpA)疾病活动性指标纵向相关。

研究人员评估了来自仁川圣玛丽axSpA前瞻性观察队列的患者数据。使用骨小梁评分(TBS)评估骨小梁缺失。使用广义估计方程(GEE)模型分析了TBS与疾病活动性指标(强直性脊柱炎疾病活动性评分[ASDAS]、巴斯强直性脊柱炎疾病活动性指数[BASDAI]、红细胞沉降率[ESR]c反应蛋白[CRP])之间的关联。

240名患者(80%为男性,平均年龄37±12岁)的4年随访数据进行评估。在基线时,根据ASDAS-ESRASDAS-CRP疾病活动性较高的患者有TBS较低的趋势(分别为p=0.003p=0.016)。单因素GEE分析显示,随着时间推移,TBS与疾病活动性指标之间存在明显关联,BASDAI除外。单因素分析显示,TBS与年龄、吸烟和脊柱结构损伤之间存在纵向关联。在多因素GEE分析中,调整混杂因素后,ASDAS-ESRASDAS-CRPESRCRPTBS纵向相关。在强直性脊柱炎患者(AS79%)中,ASDAS评分和炎性标志物与TBS纵向相关,而在非放射学axSpA患者中不相关(nr-axSpA)。在ASnr-axSpA组中,BASDAITBS没有关联。

使用TBS评估的axSpA患者骨小梁缺失与ASDAS评分、炎性标志物呈纵向相关。

原始出处:

Kwi Young Kang. Longitudinal association between trabecular bone loss and disease activity in axial spondyloarthritis: a 4 year prospective study. J Rheumatol.15 November 2019.

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    2019-11-28 lmm397
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J Rheumatol:共患病在中轴型脊柱关节病中很常见,并与疾病预后较差相关

共患病在axSpA中很常见,并与更严重的疾病相关。

Semin Arthritis Rheu:慢性背痛的结节病患者中脊柱关节炎的患病率高

炎性背痛的结节病患者中SpA的患病率升高。   这项横断面研究纳入了64例诊断为结节病的CBP患者。主诉CBP的患者接受完整的脊柱MRI和X线摄影。所有的炎

2018 APLAR建议:中轴型脊柱关节炎的治疗

2019年2月,亚太风湿病学联盟协会(APLAR)发布了中轴型脊柱关节炎的治疗建议,尽管各风湿病学会都提出了中轴型脊柱关节炎的治疗建议,本文针对特定的亚太地区人群中轴型脊柱关节炎的治疗提出的建议对临床医生具有实质性的价值。基于证据总结和共识,全文共提出了14条中轴型脊柱关节炎的治疗建议。