LANCET INFECT DIS:尽管疫苗覆盖率很高,但在西澳大利亚州发生了长期流行性腮腺炎疫情?

2019-02-02 MedSci MedSci原创

在2007 - 08年,尽管疫苗覆盖率很高,但在西澳大利亚州北部的土着居民中仍然暴发了基因型J腮腺炎。2015年3月,西澳大利亚州北部暴发了第二次长期流行性腮腺炎,并在该州农村地区广泛传播。这次爆发是由基因型G病毒引起的,并且再次主要影响原住民。本研究的目的是描述这次疫情的流行病学。 <span style="font-family:宋体;mso-ascii-font-family:Cali

2007 - 08年,尽管疫苗覆盖率很高,但在西澳大利亚州北部的土着居民中仍然暴发了基因型J腮腺炎。20153月,西澳大利亚州北部暴发了第二次长期流行性腮腺炎,并在该州农村地区广泛传播。这次爆发是由基因型G病毒引起的,并且再次主要影响原住民。本研究的目的是描述这次疫情的流行病学。

在这项以人群为基础的监测研究中,研究人员分析了来自西澳大利亚州通报传染病数据库的法定报告和公共卫生病例随访数据,以及来自澳大利亚儿童免疫接种登记册的疫苗接种信息。如果受影响的人住在或访问西澳大利亚州的活动性腮腺炎传播,并且如果通过实验室诊断流行病学确认腮腺炎感染,则会通报腮腺炎暴发病例。根据通知区域分析了土着居民和非土着居民的人口统计,疫苗接种状况和年龄标准化罹患率。通过实时RT-PCR,血清学或两者进行实验室诊断

研究发现,201531日至20161231日期间,共通报了893例疫情。在893例暴发病例中,798(89%)发生在土著居民中。893人中有40人(4%)住院,462人中有33人(7%)罹患睾丸炎。流行性腮腺炎发病率随着年龄的增长而急剧上升,在15-19岁年龄组达到峰值。419119岁的人中有371名(89%)接种了疫苗,29名(7%)接种了部分疫苗。在240名通过实时RT-PCR检测为阳性且已经过腮腺炎特异性IgGIgM检测的患者中,165例(69%)IgG阳性但IgM阴性,表明RT-PCR检测对疫苗接种人群的诊断的重要性。2007-08基因型J爆发的病例均未重复报告。

研究表明,近年来在高度接种疫苗的人群(包括土着人口)中,流行性腮腺炎疫情数量一直在增加。因此,可能需要更广泛以及优先地使用第三剂麻疹,腮腺炎和风疹疫苗来控制和预防其未来在高风险人群的爆发。应研究探索增加疫苗剂量间隔以增强疫苗保护持久性。

原始出处:

Darren W Westphal, MPhil, A protracted mumps outbreak in Western Australia despite high vaccine coverage: a population-based surveillance study

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    2020-01-06 tulenzi
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    2019-02-09 howi
  7. [GetPortalCommentsPageByObjectIdResponse(id=2038118, encodeId=fae120381185c, content=<a href='/topic/show?id=d26690569a5' target=_blank style='color:#2F92EE;'>#覆盖率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90569, encryptionId=d26690569a5, topicName=覆盖率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca772500164, createdName=ms1490123962508630, createdTime=Fri Apr 12 21:12:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1927319, encodeId=822c192e319c0, content=<a href='/topic/show?id=b95b653e389' target=_blank style='color:#2F92EE;'>#流行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65373, encryptionId=b95b653e389, topicName=流行性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Jan 06 00:12:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967649, encodeId=9817196e649eb, content=<a href='/topic/show?id=102e6538037' target=_blank style='color:#2F92EE;'>#流行性腮腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65380, encryptionId=102e6538037, topicName=流行性腮腺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Sun Jun 16 03:12:00 CST 2019, time=2019-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737270, encodeId=ba1e1e37270fe, content=<a href='/topic/show?id=f5c38541851' target=_blank style='color:#2F92EE;'>#腮腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85418, encryptionId=f5c38541851, topicName=腮腺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fabe34270299, createdName=12498561m43(暂无昵称), createdTime=Sat Jul 06 11:12:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012938, encodeId=d648201293868, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Aug 12 03:12:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829944, encodeId=382418299446b, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Feb 09 04:12:00 CST 2019, time=2019-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361511, encodeId=76021361511b6, content=<a href='/topic/show?id=41828541441' target=_blank style='color:#2F92EE;'>#腮腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85414, encryptionId=41828541441, topicName=腮腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6411176, createdName=mfx799, createdTime=Mon Feb 04 06:12:00 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483962, encodeId=e5c9148396243, content=<a href='/topic/show?id=66a666e3784' target=_blank style='color:#2F92EE;'>#澳大利亚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66737, encryptionId=66a666e3784, topicName=澳大利亚)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Feb 04 06:12:00 CST 2019, time=2019-02-04, status=1, ipAttribution=)]
    2019-02-04 mfx799
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