Gastric Cancer:绝经后妇女胆固醇水平与胃癌风险呈负相关

2021-10-15 MedSci原创 MedSci原创

众所周知,高胆固醇血症是导致心血管疾病的高风险因素,另一方面,胆固醇水平与癌症风险之间也存在相关关系。关于胃癌,多项研究表明胆固醇水平与胃癌呈负相关关系。

      众所周知,高胆固醇血症是导致血管疾病的高风险因素,另一方面,胆固醇水平与癌症风险之间也存在相关关系。关于胃癌,多项研究表明胆固醇水平与胃癌呈负相关关系。在大多数研究中,男性之间的负相关关系很突出,然而,女性中的证据并不一致,造成这种差异的原因可能是性激素,因为胆固醇是一种与性别密切相关的激素,女性性激素可能会影响癌症风险,因此,本项研究旨在根据更年期状态评估胆固醇水平与女性患胃癌风险之间的关系。

 

      研究人员对在2009年接受癌症筛查和一般健康筛查的 30 岁以上女性人群组成了前瞻性队列。并把胆固醇按照浓度水平分成了四分位数,最后根据2009年绝经状态计算了不同胆固醇与胃癌发生的风险,并进行了统计学分析。

 

       在总共 2722614 名个体中,总共发生了 17649 例胃癌病例(绝经前 3746/1180666;绝经后 13,903/1541948)。绝经后妇女的总胆固醇、高密度脂蛋白胆固醇 (HDL-C) 和低密度脂蛋白胆固醇 (LDL-C) 与胃癌风险呈负相关,其数值分别为总胆固醇(HR(95% 置信区间):0.88 (0.84–0.92);HDL-C 为 0.89 (0.85–0.92) ;LDL-C为0.92 (0.89–0.97) ,而绝经前妇女中没有统计学上风险关系。甘油三酯与绝经前和绝经后妇女的胃癌风险均不独立相关。

 

       本项研究证实胆固醇水平,包括总胆固醇、HDL-C 和 LDL-C,与绝经后妇女患胃癌的风险呈负相关,但在绝经前妇女中则不然。

 

 

原始出处:

Joo Hyun Lim. et al. Nationwide cohort study: cholesterol level is inversely related with the risk of gastric cancer among postmenopausal women. Gastric Cancer.2021.

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    2021-12-23 skhzy
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    2022-02-05 sjq027
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    2022-04-20 许安
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    2021-10-17 hmwwww
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    2021-10-17 zxxiang

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