Br J Cancer:MACROD2基因:宫颈癌中HPV病毒的整合热点基因

2020-11-23 xiaozeng MedSci原创

宫颈癌(CC)作为全球妇科癌症相关死亡的主要原因之一,其也是女性第二大常见的恶性肿瘤。尽管CC患者的临床表现有所不同,但HPV(高危人类乳头瘤病毒)感染仍是CC发生的一个重要起始事件,也是最重要的危险

宫颈癌(CC)作为全球妇科癌症相关死亡的主要原因之一,其也是女性第二大常见的恶性肿瘤。尽管CC患者的临床表现有所不同,但HPV(高危人类乳头瘤病毒)感染仍是CC发生的一个重要起始事件,也是最重要的危险因素之一。

大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在(短暂的/整合的)。该研究旨在分析预处理CCs中不同的病毒整合特征、临床参数和结果之间的联系。

HPV整合特征分布

研究人员通过在BioRAIDs研究[NCT02428842]中对272位CC患者进行了HPV双捕获以及高通量测序技术(NGS),以鉴定不同的病毒整合特征。并评估HPV的整合特征与临床、生物学和分子特征之间的相关性。

272例HPV阳性宫颈癌患者的无进展生存期

研究人员发现,相比于肛门癌,在CC中游离型HPV的发生率要低得多。研究人员鉴定了>300个不同的HPV染色体连接形式(基因间或基因内)。在CC患者中最常见的整合位点是在MACROD2基因中,其次是MIPOL1/TTC6和TP63基因。HPV的整合特征与组织学亚型、FIGO分型、患者的治疗或PFS期无关。在PIK3CA突变的肿瘤中,游离型HPV更为常见。进一步的研究显示,病毒的整合形式取决于HPV病毒的基因型,HPV18和HPV45始终是整合型的。高HPV拷贝数也与患者更长的PFS相关。


总而言之,该研究是第一项在前瞻性CC队列评估HPV整合的预后价值的相关研究,该研究发现了MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。


原始出处:

Kamal, M., Lameiras, S., Deloger, M. et al. Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site. Br J Cancer (16 November 2020).

 

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    2021-04-13 yb6560
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  3. [GetPortalCommentsPageByObjectIdResponse(id=1996382, encodeId=58cf199638248, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Apr 13 06:09:09 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857913, encodeId=3584185e913d0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 08 15:09:09 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400493, encodeId=54c1140049360, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408255, encodeId=df321408255cc, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902058, encodeId=180b90205897, content=<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a> 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 09:12:28 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901760, encodeId=56f1901e60be, content=HPV疫苗可以安排起来了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:32:31 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901676, encodeId=3a249016e622, content=MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 09:43:36 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 10518094zz
  4. [GetPortalCommentsPageByObjectIdResponse(id=1996382, encodeId=58cf199638248, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Apr 13 06:09:09 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857913, encodeId=3584185e913d0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 08 15:09:09 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400493, encodeId=54c1140049360, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408255, encodeId=df321408255cc, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902058, encodeId=180b90205897, content=<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a> 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 09:12:28 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901760, encodeId=56f1901e60be, content=HPV疫苗可以安排起来了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:32:31 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901676, encodeId=3a249016e622, content=MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 09:43:36 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1996382, encodeId=58cf199638248, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Apr 13 06:09:09 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857913, encodeId=3584185e913d0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 08 15:09:09 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400493, encodeId=54c1140049360, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408255, encodeId=df321408255cc, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902058, encodeId=180b90205897, content=<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a> 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 09:12:28 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901760, encodeId=56f1901e60be, content=HPV疫苗可以安排起来了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:32:31 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901676, encodeId=3a249016e622, content=MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 09:43:36 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-25 BJying

    #宫颈癌# 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1996382, encodeId=58cf199638248, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Apr 13 06:09:09 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857913, encodeId=3584185e913d0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 08 15:09:09 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400493, encodeId=54c1140049360, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408255, encodeId=df321408255cc, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902058, encodeId=180b90205897, content=<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a> 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 09:12:28 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901760, encodeId=56f1901e60be, content=HPV疫苗可以安排起来了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:32:31 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901676, encodeId=3a249016e622, content=MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 09:43:36 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-24 Jessie Zhang

    HPV疫苗可以安排起来了。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1996382, encodeId=58cf199638248, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Apr 13 06:09:09 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857913, encodeId=3584185e913d0, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Aug 08 15:09:09 CST 2021, time=2021-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400493, encodeId=54c1140049360, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408255, encodeId=df321408255cc, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Wed Nov 25 13:09:09 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902058, encodeId=180b90205897, content=<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a> 宫颈癌(CC)是全球妇科癌症相关死亡的主要原因之一,大多数HPV的感染会由免疫系统进行自发清除,但在某些情况下,其会持续存在并导致癌症的发生。感染后,病毒可以保持游离形式,也可能会整合到宿主的基因组中,这两种模式可能共同存在。也引发了对于究竟是否要接种HPV疫苗的思考。, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/a16c22989a2247c0a54b44d3e3acdaaa/44abb281938b4e04bc086f8345254626.jpg, createdBy=fb825296401, createdName=BJying, createdTime=Wed Nov 25 09:12:28 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901760, encodeId=56f1901e60be, content=HPV疫苗可以安排起来了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:32:31 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901676, encodeId=3a249016e622, content=MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。<a href='/topic/show?id=146246308d1' target=_blank style='color:#2F92EE;'>#宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46308, encryptionId=146246308d1, topicName=宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 09:43:36 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-24 Oranhyg

    MACROD2基因是HPV的一个整合热点,该基因能够影响PARP1活性受损和染色体的不稳定。#宫颈癌#

    0

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