Eur Heart J:免疫检查点抑制剂相关心肌炎的心血管磁共振特征分析

2020-03-01 xing.T MedSci原创

由此可见,这些数据表明,在排除ICI相关性心肌炎时,应谨慎使用LGE或仅使用定性T2加权STIR法。

心肌炎是免疫检查点抑制剂(ICI)治疗的潜在致命并发症。关于在ICI相关性心肌炎患者中进行心血管磁共振(CMR)检查的数据很少。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,在这项研究中,研究人员介绍了ICI相关性心肌炎患者的CMR特征,以及CMR特征与心血管事件之间的关联。

研究人员从ICI相关性心肌炎患者的国际登记处,收集了患者的临床、CMR和组织病理学数据。主要的不良心血管事件(MACE)是心血管死亡、心源性休克、心脏骤停和完全传导阻滞的综合事件。

在103位接受CMR检查且诊断为ICI相关性心肌炎患者中,平均左心室射血分数(LVEF)为50%,其中61%的患者LVEF≥50%。48%的患者存在晚期钆增强(LGE),EF降低的患者占55%,EF正常的患者占队列的43%。总体上有28%的患者存在升高的T2加权短时间反转恢复序列(STIR)信号,EF降低的患者占30%,EF正常的患者占26%。LGE比例从入院4天内进行CMR检查时的21.6%增加到入院第4天或更晚进行CMR检查时的72.0%。56例患者有心脏病理学结果。35%的病理性纤维化患者存在LGE,淋巴细胞浸润的患者中T2加权STIR信号升高的比例为26%。在5个月的随访时间内,有41名患者(40%)发生了MACE。LGE、LGE模式或T2加权STIR信号升高与MACE无关。

由此可见,这些数据表明,在排除ICI相关性心肌炎时,应谨慎使用LGE或仅使用定性T2加权STIR法。

原始出处:

Lili Zhang,et al.Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.Eur Heart J.2020.https://doi.org/10.1093/eurheartj/ehaa051

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    2020-05-06 jklm09
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    2020-03-03 zhaojie88
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    2020-03-03 slcumt

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