Burns:严重烧伤患者急性肾损伤模型的建立

2022-03-31 医路坦克 MedSci原创

在严重烧伤患者中,发病率和死亡率很高,与预后不良相关的一个因素是急性肾损伤,这项研究的目标是创建一个决策树,用于评估严重烧伤患者急性肾损伤的风险。

严重烧伤患者的死亡率从1.4%到18%。有几种评分系统被用来预测创伤的严重程度。损伤严重程度评分(ISS)是其中最常用的。然后,烧伤严重程度评分(BISS)通过将ISS评分与烧伤患者的年龄和总烧伤表面积(TBSA)相乘得到。急性肾损伤(AKI)被描述为肾功能的突然损害;AKI是严重烧伤的常见主要并发症,可能受益于肾脏替代疗法(RRT)]。研究记录了30%的患者在烧伤后发生AKI,并报告了AKI患者的死亡率在50%至80%之间。在严重烧伤患者中,发病率和死亡率很高。与预后不良相关的一个因素是急性肾损伤。根据AKIN标准,急性肾损伤根据尿量、血肌酐水平和肾脏替代治疗分为3个阶段。在这项研究中,我们的目标是创建一个决策树,用于评估严重烧伤患者急性肾损伤的风险。

我们对2000年1月至2020年3月在巴斯肯特大学安卡拉和科尼亚烧伤中心治疗的437名成年患者进行了回顾性评估,这些患者的烧伤面积占烧伤总面积的20%。有高压烧伤和既往肾脏病史的患者被排除在外。评估患者的人口学特征、病史、损伤机制、吸入性损伤的存在、烧伤深度、实验室指标、是否有少尿、是否需要肾脏替代治疗、中心静脉压以及预后。这些数据被用于“决策树方法”,以创建巴斯肯特大学的模型,以评估严重烧伤患者急性肾损伤的风险。

我们的模型对风险估计的准确率为71.09%。在172名患者中,78名(45%)有不同程度的急性肾损伤,其中26名(15.1%)接受了肾脏替代治疗。我们的模型显示,烧伤总面积是判断急性肾损伤发生的最重要因素。其他重要因素包括血肌酸值、烧伤严重程度评分、血红蛋白值、中性粒细胞/淋巴细胞比率和血小板计数。

该急性肾损伤模型可能有助于确定烧伤患者急性肾损伤的风险。这一决定将使高危患者能够在早期得到适当的治疗,减少急性肾损伤的发生率。

文献来源:Karakaya E,  Akdur A,  Aydoğan C, A model for acute kidney injury in severe burn patients.Burns 2022 02;48(1) 

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    学习

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    2022-03-31 ms7000001906418137

    学习了👍

    0

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    2022-03-31 仁术2021

    不错,学习了。

    0

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