JAHA:青年人总胆固醇水平变化对心血管疾病的影响!

2018-06-13 xing.T MedSci原创

由此可见,该研究的结果表明,胆固醇水平升高与年轻人的升高的CVD风险有关。此外,胆固醇水平降低的年轻人心血管疾病的风险降低。

虽然年轻人升高血清胆固醇被认为是心血管事件的预测因子,但没有足够的证据表明胆固醇水平变化与心血管疾病(CVD)之间存在关联。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在评估胆固醇变化是否与青年人CVD的发病率有关。

研究人员评估了2682045名年轻人(年龄在20岁至39岁),他们在2002至2005年间接受了韩国国家健康保险服务2次连续的国家健康检查。胆固醇水平分为低(<180mg/dL)、中(180-240mg/dL)和高(240mg/dl)三个水平。CVD事件定义为随访10年期间因CVD住院超过2天。

升高的胆固醇水平与缺血性心脏病风险增加(低水平-高水平组调整后的风险比[aHR]=1.21;95%可信区间[CI]=1.03-1.42和中等水平-高水平组aHR=1.21;95%CI=1.15-1.27)和脑血管疾病(CEVD)风险(低水平-高水平组aHR=1.24;95%CI=1.05-1.47,中等水平-高水平组aHR=1.09;95%CI=1.02-1.16)有关。降低的胆固醇水平与缺血性心脏病风险降低有关(中等水平-低水平组aHR=0.91;95% CI=0.88-0.95),高水平-低水平组aHR=0.65;95%CI=0.56-0.75,高水平-中等水平组aHR=0.68;95%CI=0.65-0.73)。此外,与持续高胆固醇血症患者相比,高水平-低水平组脑血管病风险降低(aHR=0.76;95%CI=0.62-0.92)。

由此可见,该研究的结果表明,胆固醇水平升高与年轻人的升高的CVD风险有关。此外,胆固醇水平降低的年轻人心血管疾病的风险降低。

原始出处:

Su Min Jeong,.et al. Effect of Change in Total Cholesterol Levels on Cardiovascular Disease Among Young Adults.JAHA.2018. https://doi.org/10.1161/JAHA.118.008819

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    2019-04-19 zll0625
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    2018-06-23 虈亣靌

    学习了涨知识了!

    0

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    2018-06-15 zhaohui6731
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