Eur Respir J:持续气道正压通气对睡眠呼吸暂停的女性患者血压和代谢的影响!

2017-08-15 xing.T MedSci原创

由此可见,在中重度女性OSA患者中,与保守治疗相比,12 周CPAP治疗可以改善血压,尤其是舒张压,但是不改变代谢指标。

持续气道正压通气(CPAP)可降低伴有阻塞性睡眠呼吸暂停(OSA)的高血压患者血压水平。然而,CPAP对女性血压和代谢状况中的作用尚未进行评估。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,在这项研究中,研究人员评估了CPAP对中重度OSA女性患者血压水平以及血糖和血脂的影响。

这项多中心、公开分组的随机对照试验是在19个西班牙睡眠中心完成,307名妇女被诊断患有中度到重度OSA(呼吸暂停低通气指数≥15次事件每小时)。妇女被随机分为持续气道正压通气(n=151)或保守治疗(n=156),治疗12 周。研究人员评估了两组患者血压变化以及血糖和血脂的变化。

与对照组相比,研究人员发现CPAP组患者舒张压降低更加明显(-2.04mmHg,95%可信区间为-4.02至-0.05;P=0.045),而收缩压(-1.54mmHg,95%可信区间为-4.58至-1.51;P=0.32)和平均血压(-1.90mmHg,95%可信区间为-4至-0.31;P=0.084)下降并不显著。CPAP治疗并没有改变任何评估的代谢变量。

由此可见,在中重度女性OSA患者中,与保守治疗相比,12 周CPAP治疗可以改善血压,尤其是舒张压,但是不改变代谢指标。

原始出处:

Francisco Campos-Rodriguez,et al. Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea. Eur Respir J. http://erj.ersjournals.com/content/50/2/1700257

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    2017-08-15 thlabcde

    好饿逆袭好东西学习了!

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