JACC:跨瓣血流和性别对外科主动脉瓣置换术死亡率的影响

2020-04-22 MedSci原创 MedSci原创

跨瓣流速、压差、性别及其相互作用对接受外科主动脉瓣置换术(AVR)的重度主动脉瓣狭窄患者的死亡率影响尚不清楚。本研究旨在比较术前跨瓣流速压差模式对AVR术后死亡率的影响,并探讨是否存在性别差异。

跨瓣流速、压差、性别及其相互作用对接受外科主动脉瓣置换术(AVR)的重度主动脉瓣狭窄患者的死亡率影响尚不清楚。本研究旨在比较术前跨瓣流速压差模式对AVR术后死亡率的影响,并探讨是否存在性别差异。

本研究纳入分析了1490名接受AVR治疗的患者(女性占37%),其中601例患者(40%)高压差但血流正常(NF),405例(27%)低压差血流正常(LG),246例(17%)反常低流量(LF)/HG,238例(16%)LF/LG。经过平均2.42年时间随访,有167名患者死亡,LF/HG患者AVR后死亡率最高(p<0.01)。LF/LG和NF/LG患者的预后与NF/HG相当(p≥0.47)。男女性的最佳脑卒中容积指数阈值分别是(40 ml/m2)和(32 ml/m2)。使用这些性别特异性切点,反常的LF与女性(校正HR:2.05;95%CI:1.21-3.47;p<0.01)和男性(校正HR:1.54;95%CI:1.02-2.32;p=0.042)的死亡率增加独立相关。

研究结果显示,反常的LF/HG与AVR后较高的死亡率相关,提示即使是高压差的主动脉狭窄患者,血流减少也是疾病严重程度的标志。

原始出处:

Ezequiel G et al.Transvalvular Flow, Sex, and Survival After Valve Replacement Surgery in Patients With Severe Aortic Stenosis.JACC.2020 Apr.

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    2020-06-12 hbwxf
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    2020-08-14 yxch48
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