Clinica Chimica Acta:血清网膜-1浓度对急性脑出血患者功能预后的影响

2020-04-13 MedSci原创 MedSci原创

血清omentin-1浓度降低可能与急性缺血性卒中后功能不良预后风险增加有关。本研究探讨血清网膜-1是否可能成为一个有前途的急性脑出血预后生物标志物。

血清omentin-1浓度降低可能与急性缺血性卒中后功能不良预后风险增加有关。本研究探讨血清网膜-1是否可能成为一个有前途的急性脑出血预后生物标志物。

研究过程中,共有104名连续的出血性中风患者接受了90天的随访。改良Rankin评分>2为预后不良。建立了多变量logistic模型以评估血清omentin-1浓度与功能预后之间的关系。

研究结果显示,血清网膜肽-1浓度中位数为147.9 ng/ml(四分位间值为114.7-199.8 ng/ml),随Rankin评分的升高而显著下降(P < 0.001)。血清omentin-1浓度<147.9 ng/ml与90天预后差的风险增高(优势比3.789;95%置信区间,1.819-8.608;P = 0.018)。在受试者工作特征曲线下,选择179.7 ng/ml为血清网膜-1浓度的最优值,对有90天不良预后风险的患者,其敏感性值为0.88,特异性值为0.70(曲线下面积为0.82;95%置信区间,0.73-0.89)。

研究表明,低浓度的血清网膜蛋白1与出血性脑卒中后较差的功能预后密切相关,证实血清网膜蛋白1是急性脑出血的一种潜在的预后生物标志物。

原始出处:

Guo-Hai Zhang,Zhe-Hao Ye,Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients

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