JACC:肾去神经术在高风险高血压患者中的应用

2020-06-12 MedSci原创 MedSci原创

肾失神经术(RDN)正在研究用于治疗不受控制的高血压,可能是一种对心血管(CV)高风险患者有吸引力的治疗方法。确定基线CV风险是否影响RDN的疗效是很重要的。本研究的目的是评估高风险高血压患者RDN后

肾失神经术(RDN)正在研究用于治疗不受控制的高血压,可能是一种对血管(CV)高风险患者有吸引力的治疗方法。确定基线CV风险是否影响RDN的疗效是很重要的。本研究的目的是评估高风险高血压患者RDN后血压(BP)降低和不良事件发生率。

本研究纳入分析了GSR数据库中的2652名接受RDN治疗的不可控高血压患者,经过3年的随访后,患者的整体24h收缩压的平均减少幅度为-8.9 ± 20.1 mm Hg,对于顽固性高血压患者的平均减少幅度为-10.4 ± 21.0 mm Hg,年龄≥65岁患者的减少幅度为-8.7 ± 17.4 mm Hg,伴有糖尿病患者的减少幅度为-10.2 ± 17.9 mm Hg,孤立性收缩压升高患者的减少幅度为-8.6 ± 18.7 mm Hg,伴有慢性肾脏疾病患者的减少幅度为-10.1 ± 20.3 mm Hg,伴有房颤患者的减少幅度为-10.0 ± 19.1 mm Hg(所有p < 0.0001)。另外,基线CV风险较高的患者3年的不良事件发生率较高。

研究结果显示,RDN术后血压的降低幅度在合并不同并发症患者中是相似的,无明显差异。

原始出处:

Felix M et al.Renal Denervation in High-Risk Patients With Hypertension.JACC.2020 June.

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    2020-08-06 hbwxf
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