Clinical Nutrition: 补充短双歧杆菌可改善肥胖儿童和青少年的胰岛素敏感性

2021-06-18 MedSci原创 MedSci原创

肥胖是与代谢、心血管、呼吸系统疾病和癌症等多种疾病相关的重要公共卫生问题之一。在全球范围内,肥胖症的患病率迅速增加。

      肥胖是与代谢、血管、呼吸系统疾病和癌症等多种疾病相关的重要公共卫生问题之一。在全球范围内,肥胖症的患病率迅速增加,2017 年肥胖影响了 6.037 亿成年人和 1.077 亿儿童除了遗传、行为和环境因素外,肠道微生物群已被认为是导致肥胖的另一个原因。肥胖个体,包括儿童,呈现出不同的微生物群组成,比如生物多样性减少,特定种群比例改变,例如双歧杆菌水平降低和普氏菌水平增加。本项研究旨在评估益生菌补充剂对儿童肥胖症对体重、代谢改变、肠道微生物群和功能的影响。

 

      研究人员对101名肥胖且有胰岛素抵抗的青年(6-18 岁,Tanner 分期 ≥2)随机分配至接受益生菌治疗( 2×10 9 CFU/AFU/天的短双歧杆菌BR03(DSM 16604)和短双歧杆菌B632(DSM 24706)组 或安慰剂组治疗8 周。

 

      研究结果显示:所有受试者都没有出现不良事件而且所有受试者都改善了代谢参数,并减少了体重和大肠杆菌数量。益生菌改善了禁食和 糖耐量实验(OGTT)期间的胰岛素敏感性。细胞因子、GLP-1 和目标微生物计数没有变化。在 25 种短链脂肪酸( SCFA )中,乙酸和乙酸戊酯的相对丰度在益生菌中保持稳定,而在安慰剂中增加(p < 0.02)。

图:胰岛素敏感性的危险因素

      本项研究证实用短双歧杆菌BR03 和 B632治疗 8 周对肥胖青年的胰岛素敏感性产生有益影响。微生物群功能可能会影响对益生菌的代谢反应。

 

 

原始出处:

Arianna Solito. Et al. Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial. Clinical Nutrition.2021.

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    2021-09-14 baoya
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