AP&T: 粪便菌群移植可降低重症患者和难治性梭状芽胞杆菌感染患者的死亡率

2019-11-28 不详 MedSci原创

重症度和暴发性艰难梭菌感染与高死亡率有关。尽管已证明粪便微生物菌群移植对于复发性艰难梭菌感染有效,但关于严重或难治性艰难梭菌感染,粪便微生物菌群移植的效用数据很少。因此,本项研究比较了重症或暴发性艰难梭菌感染的危重患者的抗生素和粪便微生物群移植与单独使用抗生素的结果。

背景
重症度和暴发性艰难梭菌感染与高死亡率有关。尽管已证明粪便微生物菌群移植对于复发性艰难梭菌感染有效,但关于严重或难治性艰难梭菌感染,粪便微生物菌群移植的效用数据很少。因此,本项研究比较了重症或暴发性艰难梭菌感染的危重患者的抗生素和粪便微生物群移植与单独使用抗生素的结果。

方法
这是一项回顾性配对研究,其中包括48位因重度或暴发性艰难梭菌感染住院的患者,都需要在重症监护室进行护理。

结果
接受粪便微生物群移植的患者(n = 16)的死亡率降低了77%(OR 0.23,95%CI 0.06-0.97)。

结论
粪便菌群移植可以降低重度和暴发性艰难梭菌感染患者的死亡率,在重症患者中应考虑使用。

原始出处:

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    2019-11-30 Homburg
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    2019-11-30 freve
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    2019-11-29 飛歌

    学习了很有用不错

    0

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