Liver Int:孕酮受体的突变使HIV阳性的患者易感戊型肝炎

2018-01-23 MedSci MedSci原创

研究发现,孕酮的一个突变,为免疫抑制个体易感HEV感染,提供了一个研究思路。

免疫缺陷宿主感染戊型肝炎病毒(HEV)可导致慢性肝病。在移植受者中,使用某些免疫抑制剂和饮食习惯被认为是感染HEV的危险因素。在人类免疫缺陷病毒(HIV)感染的个体,HEV感染的危险因素尚不清楚。本研究的目的是研究在艾滋病毒阳性的个体中,孕酮受体(PROGINS)基因突变与HEV感染间的关系。

研究通过KASP对64名HIV阳性的患者和187例健康对照者的血清样本进行评估,评估PROGINS出现的频率。采用ELISA方法,检测IL-10、IL-12的血清水平。同时进行外周血T细胞刺激实验,以评估存在PROGINS基因突变患者的免疫反应。

研究发现,在HIV患者中,PROGINS突变与HEV血清阳性率显著相关(30% in HIV+/HEV+ versus 2% in HIV+/HEV, P = .009)。研究进一步发现,存在PROGINS突变的HIV+/HEV+患者,血清IL-10的血清水平降低,IL-12的血清水平增高。与未突变患者相比,PROGINS的突变,导致了患者对CD4+和CD8+T细胞的刺激反应减弱,这表明PROGINS与免疫调节有关。

研究发现,孕酮受体的一个突变,为免疫抑制个体易感HEV感染,提供了一个研究思路。

原始出处


Debes JD, Pas SD, Groothuismink Z, et al. A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients. Liver Int, 2017, Dec 28. doi: 10.1111/liv.13678.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1987128, encodeId=74e3198e1280e, content=<a href='/topic/show?id=785545324fd' target=_blank style='color:#2F92EE;'>#孕酮受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45324, encryptionId=785545324fd, topicName=孕酮受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Wed Sep 05 15:15:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282225, encodeId=e600282225d6, content=谢谢分享.受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jan 26 13:36:48 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443100, encodeId=ce49144310045, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471041, encodeId=75b914e1041db, content=<a href='/topic/show?id=0b1445323b0' target=_blank style='color:#2F92EE;'>#孕酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45323, encryptionId=0b1445323b0, topicName=孕酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575306, encodeId=e2a615e530693, content=<a href='/topic/show?id=28138930d2' target=_blank style='color:#2F92EE;'>#HIV阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8930, encryptionId=28138930d2, topicName=HIV阳性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e5e16086652, createdName=zxl734, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1987128, encodeId=74e3198e1280e, content=<a href='/topic/show?id=785545324fd' target=_blank style='color:#2F92EE;'>#孕酮受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45324, encryptionId=785545324fd, topicName=孕酮受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Wed Sep 05 15:15:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282225, encodeId=e600282225d6, content=谢谢分享.受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jan 26 13:36:48 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443100, encodeId=ce49144310045, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471041, encodeId=75b914e1041db, content=<a href='/topic/show?id=0b1445323b0' target=_blank style='color:#2F92EE;'>#孕酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45323, encryptionId=0b1445323b0, topicName=孕酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575306, encodeId=e2a615e530693, content=<a href='/topic/show?id=28138930d2' target=_blank style='color:#2F92EE;'>#HIV阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8930, encryptionId=28138930d2, topicName=HIV阳性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e5e16086652, createdName=zxl734, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-26 虈亣靌

    谢谢分享.受益匪浅

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1987128, encodeId=74e3198e1280e, content=<a href='/topic/show?id=785545324fd' target=_blank style='color:#2F92EE;'>#孕酮受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45324, encryptionId=785545324fd, topicName=孕酮受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Wed Sep 05 15:15:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282225, encodeId=e600282225d6, content=谢谢分享.受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jan 26 13:36:48 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443100, encodeId=ce49144310045, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471041, encodeId=75b914e1041db, content=<a href='/topic/show?id=0b1445323b0' target=_blank style='color:#2F92EE;'>#孕酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45323, encryptionId=0b1445323b0, topicName=孕酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575306, encodeId=e2a615e530693, content=<a href='/topic/show?id=28138930d2' target=_blank style='color:#2F92EE;'>#HIV阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8930, encryptionId=28138930d2, topicName=HIV阳性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e5e16086652, createdName=zxl734, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1987128, encodeId=74e3198e1280e, content=<a href='/topic/show?id=785545324fd' target=_blank style='color:#2F92EE;'>#孕酮受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45324, encryptionId=785545324fd, topicName=孕酮受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Wed Sep 05 15:15:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282225, encodeId=e600282225d6, content=谢谢分享.受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jan 26 13:36:48 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443100, encodeId=ce49144310045, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471041, encodeId=75b914e1041db, content=<a href='/topic/show?id=0b1445323b0' target=_blank style='color:#2F92EE;'>#孕酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45323, encryptionId=0b1445323b0, topicName=孕酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575306, encodeId=e2a615e530693, content=<a href='/topic/show?id=28138930d2' target=_blank style='color:#2F92EE;'>#HIV阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8930, encryptionId=28138930d2, topicName=HIV阳性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e5e16086652, createdName=zxl734, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1987128, encodeId=74e3198e1280e, content=<a href='/topic/show?id=785545324fd' target=_blank style='color:#2F92EE;'>#孕酮受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45324, encryptionId=785545324fd, topicName=孕酮受体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Wed Sep 05 15:15:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282225, encodeId=e600282225d6, content=谢谢分享.受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jan 26 13:36:48 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443100, encodeId=ce49144310045, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471041, encodeId=75b914e1041db, content=<a href='/topic/show?id=0b1445323b0' target=_blank style='color:#2F92EE;'>#孕酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45323, encryptionId=0b1445323b0, topicName=孕酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575306, encodeId=e2a615e530693, content=<a href='/topic/show?id=28138930d2' target=_blank style='color:#2F92EE;'>#HIV阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8930, encryptionId=28138930d2, topicName=HIV阳性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e5e16086652, createdName=zxl734, createdTime=Thu Jan 25 10:15:00 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 zxl734

相关资讯

Lancet:度鲁特韦联合利匹韦林治疗HIV-1型III期临床研究

研究认为,度鲁特韦联合利匹韦林治疗48周的效果非劣于现行HIV联合治疗方案

Sci Immun:新发现为改进HIV和丙肝疫苗提供新思路

近日,加州的研究人员发现了CD4细胞毒性T细胞是如何发展的,这或将打开改进艾滋病病毒和丙肝病毒疫苗设计的大门。相关研究结果在线发表在2018年1月19日的《Science Immunology》上。

PLoS Pathog:加拿大专家解密女性艾滋病感染者居高不下的原因,根源原来在这里

第一项同类研究发现,人类免疫缺陷病毒1型(HIV-1)在早期感染期间阴道内的遗传多样性高于血流中的遗传多样性。这一发现发表在《PLOS病原体》杂志上,证实了阴道和血液之间存在着遗传瓶颈。

恒瑞3.5亿美元转让BTK抑制剂,全球很大HIV组织怒斥吉利德“无耻”……

本周,总局发布《接受医疗器械境外临床试验数据技术指导原则》,彻底与国际接轨,允许器械公司在境内外开展临床试验;而《医疗器械网络销售监督管理办法》则将于3月1日正式施行。企业方面,备受关注的莫过于JP摩根大会,Shire宣布可能将拆分成两家公司,Teva继续精简公司架构,GSK组建管理层的“梦之队”……

Lancet HIV:CD4计数与HIV抗逆转录病毒药物治疗收益

研究发现,对于无症状的,未接受过抗病毒治疗的,CD4计数超过500的HIV感染者,若患者年龄超过50岁,CD4/CD8低以及HIV病毒当量较高时,这部分患者进行立即的抗病毒治疗受益显著,应当考虑优先治疗

Thorax:HIV感染与气流限制分析!

由此可见,HIV是FEV1和FVC同时降低的危险因素。这种过度的风险不是由吸烟或社会经济状况来解释的,可能是由先前的免疫缺陷所介导的。