J Periodontol:中性粒细胞是牙周炎进展中组胺和嗜酸性粒细胞阳离子蛋白的来源

2018-04-01 MedSci MedSci原创

牙周炎通过由微生物生物膜感染引起的炎症过程发展,然后是由白细胞介导的组织破坏,可引起临床上明显的结缔组织和骨的破坏。来源于细菌的几种成分引起炎症反应和与牙周膜破坏有关的介质的释放。在细菌攻击时,白细胞释放的炎性介质主要是嗜中性粒细胞。嗜中性粒细胞产生并释放嗜酸性粒细胞阳离子蛋白(ECP)和组胺两种重要的炎症介质,然而其在牙周炎症中的作用尚未表征。因此,本研究旨在调查牙周炎患者的中性粒细胞是否可以产

牙周炎通过由微生物生物膜感染引起的炎症过程发展,然后是由白细胞介导的组织破坏,可引起临床上明显的结缔组织和骨的破坏。来源于细菌的几种成分引起炎症反应和与牙周膜破坏有关的介质的释放。

在细菌攻击时,白细胞释放的炎性介质主要是嗜中性粒细胞。嗜中性粒细胞产生并释放嗜酸性粒细胞阳离子蛋白(ECP)和组胺两种重要的炎症介质,然而其在牙周炎症中的作用尚未表征。因此,本研究旨在调查牙周炎患者的中性粒细胞是否可以产生ECP和组胺对脂多糖(LPS)的反应。

通过酶联免疫吸附试验分析ECP和组胺产生对LPS的反应。通过流式细胞术和荧光显微镜检查来自患有牙周炎的患者的中性粒细胞响应于LPS的组蛋白脱羧酶和ECP的表达。

结果显示,来自牙周炎患者的中性粒细胞表达组氨酸脱羧酶和ECP的水平高于健康志愿者,并且它们也释放更高水平的组胺。

综上所述,该研究结果表明中性粒细胞是牙周炎进展中组胺和ECP的来源。

原始出处:

Ribas D, Fernández-Carranco MC, et al., Eosinophil cationic protein and histamine production by neutrophils from patients with periodontitis. J Periodontol. 2018 Feb;89(2):228-234. doi: 10.1902/jop.2017.160679. Epub 2018 Feb 20.

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    2018-04-23 feather89

    #PE#

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    2018-11-06 bluefate133

    #组胺#

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    2018-04-03 yykkxiaodou
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  5. 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    2018-04-03 liuyong2982

    #牙周#

    0

  6. 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    2018-04-03 wzb521zf

    一起学习学习学习

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 02 06:56:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301894, encodeId=028a30189480, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Mon Apr 02 05:23:49 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301883, encodeId=1f9a30188373, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Mon Apr 02 00:47:07 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-03 changjiu

    学习一下谢谢

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Apr 03 06:37:48 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302223, encodeId=6f3a3022238b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Apr 03 03:01:39 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301951, encodeId=2701301951e4, content=不错学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 02 06:56:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301894, encodeId=028a30189480, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Mon Apr 02 05:23:49 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301883, encodeId=1f9a30188373, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Mon Apr 02 00:47:07 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-02 飛歌

    不错学习了很有用

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Apr 03 06:37:48 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302223, encodeId=6f3a3022238b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Apr 03 03:01:39 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301951, encodeId=2701301951e4, content=不错学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 02 06:56:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301894, encodeId=028a30189480, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Mon Apr 02 05:23:49 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301883, encodeId=1f9a30188373, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Mon Apr 02 00:47:07 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-02 121832a9m88暂无昵称

    学习了

    0

  10. 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channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Mon Apr 02 00:47:07 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-02 xiaotaiyang1

    看看了解一下.谢谢分享

    0