Intern Med:非酒精性脂肪性肝炎患者自身免疫性胃炎高发

2020-03-03 不详 网络

本研究旨在评估非酒精性脂肪性肝炎(NASH)的患者自身免疫性胃炎的患病率。回顾性评估2013年1月至2016年8月期间接受上消化道内镜检查33例NASH患者和143例慢性肝病患者(66例丙型肝炎,24例乙型肝炎、22例自身免疫性肝炎/原发性胆管性胆管炎、10例非乙型/非丙型肝炎、1例脂肪肝和21例酒精性疾病),以确定自身免疫性胃炎的患病率。检查了这些患有NASH和自身免疫性胃炎的患者的临床特征,并

本研究旨在评估非酒精性脂肪性肝炎(NASH)的患者自身免疫炎的患病率。

回顾性评估2013年1月至2016年8月期间接受上消化道内镜检查33例NASH患者和143例慢性肝病患者(66例丙型肝炎,24例乙型肝炎、22例自身免疫性肝炎/原发性胆管性胆管炎、10例非乙型/非丙型肝炎、1例脂肪肝和21例酒精性疾病),以确定自身免疫性炎的患病率。检查了这些患有NASH和自身免疫性胃炎的患者的临床特征,并比较了患有和不患有自身免疫性胃炎的NASH患者的临床特征和生物标志物。

结果显示,在33例NASH患者中,有6例(19.4%)被诊断出患有自身免疫性胃炎。NASH患者的自身免疫性胃炎患病率高于其他慢性肝病患者[4/143(2.8%),p = 0.002]。 6例NASH和自身免疫性胃炎患者均表现出较高的血清胃泌素水平。其中五名患者的抗壁细胞抗体阳性,一名患者的抗壁细胞抗体阴性,但内在因子抗体阳性。此外,1例患者出现铁缺乏性贫血(血红蛋白<11 g/dL),但均未发生恶性贫血。在四名患者中发现了内分泌细胞微巢。具有NASH和自身免疫性胃炎的患者往往比其他患者年龄更大,铁蛋白水平较低。

总之,该研究结果表明,伴有自身免疫性胃炎的NASH患病率很高,这突出显示了需要使用上镜检查来诊断自身免疫性胃炎和胃恶性肿瘤。

原始出处:

Miwa Kawanaka, Tomohiro Tanikawa, et al.,High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis. Intern Med. 2019 Oct 15; 58(20): 2907–2913.  doi: 10.2169/internalmedicine.2693-19

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    2020-08-29 qjddjq
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