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Methods Mol Biol：氧诱导视网膜病变模型的建立及应用

2018-11-12 MedSci MedSci原创

氧诱导视网膜病变模型应用
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德国慕尼黑路德维希马克西米利安大学医院眼科的Liegl R和Priglinger C等人近日在Methods Mol Biol杂志上发表了一篇综述，他们详细讨论了氧诱导视网膜病变模型的建立及应用。

德国慕尼黑路德维希马克西米利安大学医院眼科的Liegl R和Priglinger C等人近日在Methods Mol Biol杂志上发表了一篇综述，他们详细讨论了氧诱导视网膜病变模型的建立及应用。

缺血性视网膜疾病可能由各种病理原因造成，这常常引起视网膜前的新血管形成。氧诱导的视网膜病变小鼠模型是研究正常和病理性视网膜中血管生成机制的一种非常常见且成熟的模型。该模型构建过程是在视网膜血管发育期间，将小鼠幼崽暴露在富氧的环境中，引起视网膜毛细血管萎缩。当放回到室内空气后，由于缺乏视网膜脉管系统导致缺氧，进而引起血管修复和视网膜前的新血管形成。

在这篇综述中，他们重点讨论了对OIR模型的科学选择、实际实验和量化过程，对其潜在的缺陷也进行了讨论。

原文出处：

Liegl， R.， C. Priglinger， and A. Ohlmann， Induction and Readout of Oxygen-Induced Retinopathy. Methods Mol Biol， 2019. 1834： p. 179-191.

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    2018-11-24 一闲

    #MET#

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    2018-12-28 12498ebem31暂无昵称

    #Biol#

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    2019-02-05 sunylz

    #Bio#

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    2018-11-14 zutt

    #视网膜#

    0

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    2018-11-14 智者为医08

    #视网膜病变#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1896417, encodeId=9c7f189641ed0, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Nov 24 02:19:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767556, encodeId=42ee1e67556c9, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Dec 28 21:19:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918393, encodeId=ad1619183934a, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Feb 05 19:19:00 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270131, encodeId=752d12e0131d4, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Wed Nov 14 12:19:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413965, encodeId=4d6214139656b, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Nov 14 12:19:00 CST 2018, time=2018-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047636, encodeId=fe9d104e63656, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Tue Nov 13 00:19:00 CST 2018, time=2018-11-13, status=1, ipAttribution=)]
    2018-11-13 CHANGE

    梅斯里提供了很多疾病的模型计算公式，赞一个！

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