Gastroenterology:肝纤维化与非酒精性脂肪肝患者预后

2020-05-19 网络 网络

活检证实的肝纤维化导致非酒精性脂肪肝患者死亡及不良预后风险显著增加

活检证实的肝纤维化是非酒精性脂肪肝(NAFLD)患者预后的重要影响因素,近日研究人员开展系统综述及荟萃分析以量化NAFLD患者和非酒精性脂肪性肝炎(NASH)患者纤维化阶段的预后价值。
 
研究人员收集截至2018年8月的相关资料,涉及成年NAFLD或NASH患者的临床结局,包括不同纤维化阶段患者的死亡(全因及肝相关)和疾病(硬化,肝癌及肝相关事件)信息。
 
13项研究,总计包含4428名NAFLD以及2875名NASH患者。相比于无纤维化(0期)患者,4期纤维化患者的全因死亡风险为3.42、肝相关死亡风险为11.13、肝移植风险为5.42、肝事件风险为12.78,年龄及性别对风险的影响不显著。
 
研究发现,活检证实的肝纤维化导致非酒精性脂肪肝患者死亡及不良预后风险显著增加。
 
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    2020-10-13 许安
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  5. 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