Circ-Arrhythmia Elec:胸部按压时心室颤动波形或可预测患者生存率

2019-01-15 国际循环编辑部 国际循环

心室颤动(VF)心电图波形的定量测量可评估心肌生理学并预测心脏停搏结局,有助于指导心肺复苏。临床实践中,通常暂停胸部按压以进行波形测量计算,因为,按压可导致ECG假象。

心室颤动(VF)心电图波形的定量测量可评估心肌生理学并预测心脏停搏结局,有助于指导心肺复苏。临床实践中,通常暂停胸部按压以进行波形测量计算,因为,按压可导致ECG假象。然而,为最小化心肺复苏中断,这种暂停与复苏指南建议相矛盾。Circulation: Arrhythmia and Electrophysiology的这项研究评估一组综合VF测量,包括进行和不进行持续按压两种情况,以确定其在预测功能完好存活的表现,也是该研究的主要终点。

研究者在1151例院外心脏停搏患者的2755次除颤电击之前,收集有或无胸部按压的5秒VF-ECG节段。实施二十四项个体化措施和三项组合措施。使用460个训练案例优化测量以预测功能完好存活(脑功能分类评分≤2),并使用691个独立测试案例评估其性能。

结果显示,测量预测功能完好存活测试数据,无胸部按压受试者工作特征曲线下面积为0.56~0.75(中位数0.73),胸部按压者为0.53~0.75(中位数0.69)(差异P<0.001)。在评估的所有测量值中,支持向量机模型在无胸部按压(受试者工作特征曲线下面积为0.75; 95%CI:0.73~0.78)和胸部按压(受试者工作特征曲线下面积为0.75;95%CI:0.72~0.78;差异P=0.75)的情况下排名最高。

研究者得出结论,在胸部按压期间进行VF波形测量预测患者功能完好的存活,与无胸部按压分析相比,预后性能通常降低。然而,支持向量机模型在有和无胸部按压的情况下表现出类似性能,同时,在受试者工作特性曲线下面积也达最高值。因此,这种机器学习模型可提供在不间断的心肺复苏期间引导复苏操作。

原始出处:
Jason Coult, Jennifer Blackwood, Lawrence Sherman, et al. Ventricular Fibrillation Waveform Analysis During Chest Compressions to Predict Survival From Cardiac Arrest. Circulation: Arrhythmia and Electrophysiology. Jan 2019.

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    2019-11-07 lisa446
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