LANCET GASTROENTEROL:丙肝感染者动脉粥样硬化性心血管疾病的全球负担

2019-08-02 Daphné MedSci原创

背景全球有超过7千万丙肝(HCV)感染者。有新证据证明丙肝与动脉粥样硬化性心血管疾病相关。研究的目的是为了确定丙肝与心血管疾病间的关系,并估计丙肝引起的国家、区域和全球心血管疾病负担。方法为了系统的回顾和荟萃分析,研究人员搜索了MEDLINE, Embase, Ovid Global Health, and Web of Science 各数据库从成立到2018年5月9日所有语言的评估了丙肝患者和

背景
全球有超过7千万丙肝(HCV)感染者。有新证据证明丙肝与动脉粥样硬化性心血管疾病相关。研究的目的是为了确定丙肝与心血管疾病间的关系,并估计丙肝引起的国家、区域和全球心血管疾病负担。

方法
为了系统的回顾和荟萃分析,研究人员搜索了MEDLINE, Embase, Ovid Global Health, and Web of Science 各数据库从成立到2018年5月9日所有语言的评估了丙肝患者和非丙肝患者心血管疾病风险比(RR)的纵向研究。两名研究者从已发表的文献中独立审查及提取数据。主要结果是定义为因急性心肌梗死或中风而住院或死亡的心血管疾病。研究人员使用随机效应模型计算了与HCV相关心血管疾病的合并RR,此外,他们还在国家、地区和全球水平计算了人群归因风险度和伤残调整寿命年(DALYs)。研究人员同样用100个国家年龄和性别分层的HCV患病率和心血管DALYs分析与HCV相关的国家水平负担。

结果
研究搜索了16639条记录,纳入了36个研究,包括341739位HCV患者。心血管疾病的合并RR为1.28(95%CI 1.18-1.39)。每年全球有150万DALYs因HCV相关心血管疾病而失去。低收入和中等收入的国家负担最大,包括南亚、东欧、北非和中东地区,共占所有HCV相关心血管DALYs的三分之二。

结论
丙肝与心血管风险增加有关。全球负担的HCV感染相关的心血管疾病导致150万DALYs,其中低收入和中等收入国家负担最高。

原始出处
Global burden of atherosclerotic cardiovascular disease in people with hepatitis C virus infection: a systematic review, meta-analysis, and modelling study,DOI:https://doi.org/10.1016/S2468-1253(19)30227-4

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    2020-07-17 howi
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objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33302, encryptionId=a557333025c, topicName=动脉粥样硬化性心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sun Aug 04 07:52:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496345, encodeId=4a1814963456a, content=<a href='/topic/show?id=43b6e358710' target=_blank style='color:#2F92EE;'>#硬化性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73587, encryptionId=43b6e358710, topicName=硬化性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8119265602, createdName=Smile2683, createdTime=Sun Aug 04 07:52:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498608, 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09:52:00 CST 2020, time=2020-06-07, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2064793, encodeId=2ff62064e93af, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 03 01:52:00 CST 2020, time=2020-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830179, encodeId=097d18301e926, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, 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objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33302, encryptionId=a557333025c, topicName=动脉粥样硬化性心血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sun Aug 04 07:52:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496345, encodeId=4a1814963456a, content=<a href='/topic/show?id=43b6e358710' target=_blank style='color:#2F92EE;'>#硬化性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73587, encryptionId=43b6e358710, topicName=硬化性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8119265602, createdName=Smile2683, createdTime=Sun Aug 04 07:52:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498608, encodeId=4c551498608a4, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Aug 04 07:52:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804112, encodeId=5b7618041127e, content=<a href='/topic/show?id=d1b2e630123' target=_blank style='color:#2F92EE;'>#粥样硬化性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76301, encryptionId=d1b2e630123, topicName=粥样硬化性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sun Jun 07 09:52:00 CST 2020, time=2020-06-07, status=1, ipAttribution=)]
    2020-04-13 许安
  6. 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  7. 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  8. 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