Alzheimers Dement:视网膜微脉管系统与老年痴呆的相关性研究

2018-11-25 MedSci MedSci原创

美国约翰霍普金斯大学彭博公共卫生学院流行病学系的Deal JA和威斯康星大学医学与公共卫生学院眼科学与视觉科学系的Klein R等人近日在Alzheimers Dement杂志上发表了一篇重要的文章,他们研究发现,采用易于成像的视网膜微脉管系统可以反映脑微血管系统状况,脑微血管系统可能与痴呆症等有关。

美国约翰霍普金斯大学彭博公共卫生学院流行病学系的Deal JA和威斯康星大学医学与公共卫生学院眼科学与视觉科学系的Klein R等人近日在Alzheimers Dement杂志上发表了一篇重要的文章,他们研究发现,采用易于成像的视网膜微脉管系统可以反映脑微血管系统状况,脑微血管系统可能与痴呆症等有关。

在一项针对12,482名50-73岁成年人(22%非洲裔美国人)的研究中,他们研究了眼底摄影(1993-1995)的视网膜特征与全因痴呆事件的关系(1993-1995至2011-2013),分析痴呆或轻度认知障碍的病因。

他们总共研究了1259名(10%)参与者,平均患上痴呆症约15.6年。他们发现,中度或重度视网膜病变(风险比[HR],1.86; 95%置信区间[CI]:1.36-2.55)和视网膜中央小动脉当量(最窄四分位数与最宽三个四分位数; HR,1.26; 95% CI:1.09-1.45)与痴呆有关。糖尿病患者的结果相对更强,但在统计学上没有显着的差异。视网膜病变与脑血管相关,但与阿尔茨海默病或轻度认知障碍等结果相关性不大(HR,2.29; 95%CI:1.24-4.23)。

因此,他们认为,对眼睛进行检测可以替代痴呆相关的微血管病变的指标。

原文出处:

Deal, J.A., et al., Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. Alzheimers Dement, 2018.

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    2019-04-07 anminleiryan
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    2018-11-27 zutt
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    2018-11-25 junJUN

    老年人痴呆何药可用??

    0