微生物组疗法治疗癌症!复发性胶质母细胞瘤的治疗或迎来新希望

2020-07-30 Allan MedSci原创

胶质母细胞瘤是一种侵袭性脑癌,尚无治愈方法。

胶质母细胞瘤是一种侵袭性脑癌,尚无治愈方法。 

ENTEROME是一家处于临床阶段的生物制药公司,专注于利用微生物组-免疫炎症轴方面的知识来开发新型疗法,该公司今日宣布,已开始使用基于微生物组抗原(OncoMimic)的癌症免疫疗法EO2401进行首次临床试验。I/II期临床试验(ROSALIE)将研究EO2401联合免疫检查点抑制剂治疗复发性胶质母细胞瘤的有效性和安全性。ROSALIE研究的初步临床数据预计将于2022年公布。

EO2401是源自Enterome革命性OncoMimic平台的免疫肿瘤候选药物。OncoMimics是微生物组衍生的肽抗原,可模拟肿瘤细胞表达的抗原。这些抗原能够触发针对肠道细菌的记忆T细胞激活,并能触发针对肿瘤细胞的杀伤性免疫反应。

EO2401的第一项临床试验(ROSALIE,NCT04116658)是一项多中心、开放标签的I/II期研究,旨在评估其与检查点抑制剂联用治疗胶质母细胞瘤的安全性、耐受性、免疫原性和初步疗效。预计将在欧洲和美国的10个临床中心招募32位患者。

德国海德堡大学神经病学系主任Wolfgang Wick教授是ROSALIE的首席研究员。Wolfgang Wick教授是一位全球知名的神经肿瘤学家,在原发性和复发性脑肿瘤领域拥有丰富的临床研究经验。

 

原始出处:

https://www.firstwordpharma.com/node/1744925?tsid=4

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank 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  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Aug 01 12:28:53 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2021-05-15 珙桐
  6. [GetPortalCommentsPageByObjectIdResponse(id=1909831, encodeId=844f190983126, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 11 16:28:53 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052932, encodeId=0f502052932e2, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Aug 01 12:28:53 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-10-29 1378958079

    ……

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 29 21:41:01 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890626, encodeId=f2c589062648, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 08 20:45:07 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887164, encodeId=2cc688e16492, content=……, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Aug 01 12:28:53 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-10-08 1378958079

    可以

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1909831, encodeId=844f190983126, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 11 16:28:53 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052932, encodeId=0f502052932e2, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 29 21:41:01 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890626, encodeId=f2c589062648, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 08 20:45:07 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887164, encodeId=2cc688e16492, content=……, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Aug 01 12:28:53 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-09-21 1378958079

    ……

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1909831, encodeId=844f190983126, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 11 16:28:53 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052932, encodeId=0f502052932e2, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 29 21:41:01 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890626, encodeId=f2c589062648, content=可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Thu Oct 08 20:45:07 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887164, encodeId=2cc688e16492, content=……, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Aug 01 12:28:53 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-08-24 芸兜

    需要

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1909831, encodeId=844f190983126, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Apr 11 16:28:53 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052932, encodeId=0f502052932e2, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Sep 22 08:28:53 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970016, encodeId=1b5519e001675, content=<a href='/topic/show?id=ec345834075' target=_blank style='color:#2F92EE;'>#新希望#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58340, encryptionId=ec345834075, topicName=新希望)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Sat May 15 22:28:53 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895521, encodeId=9e6a89552182, content=……, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200826/39ffc551fb8f47a28b631c5ba2936b7f/67d8dfcf90a24598b1033041c7e7b5a4.jpg, createdBy=3ff14827973, createdName=1378958079, createdTime=Mon Sep 21 19:01:18 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812852, encodeId=e63881285217, content=需要, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/cNHCZhNDcfbmtibJ0eGDlxexq1srh3nRznRcYR8VyH5zXv3EXzHicwXxZp5kjM9qRTajNRqZXYW9yic82oAqugfDA/132, createdBy=11805290677, createdName=芸兜, createdTime=Mon Aug 24 23:35:55 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382440, encodeId=2e4613824407c, content=<a href='/topic/show?id=49d350e1625' target=_blank 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European Radiology:贝伐单抗治疗复发性胶质母细胞瘤失败的MR预测评估

研究报告称,从DSC MRI得出的治疗前脑血容量(CBV)可以预测无进展生存期和总生存期,从而实现患者分层。

Clin Cancer Res:口服Selinexor治疗复发性胶质母细胞瘤的疗效

复发性胶质母细胞瘤成年患者每周口服 80 mg 单剂量 Selinexor 可诱导临床缓解,获得相对较高的 6 个月无进展生存率

Front Oncol:替莫唑胺联合阿帕替尼治疗复发性胶质母细胞瘤的疗效和安全性

研究表明,阿帕替尼加替莫唑胺是复发性胶质母细胞瘤有效的挽救方案,且毒性可控,同时不降低后续贝伐单抗治疗的敏感性。

Clin Cancer Res:口服Selinexor治疗复发性胶质母细胞瘤

每周一剂塞利尼索 (selinexor) 可诱导复发性胶质母细胞瘤成人患者获得缓解

Radiology:这一影像学技术,可陪伴胶质母细胞瘤患者共同前进!

胶质母细胞瘤的典型特征是血管内皮生长因子介导的血管生成,因此临床上对该蛋白的靶向治疗产生了极大兴趣。