J Endod:瘦素通过MAPK信号通路诱导人牙髓细胞的成牙本质分化和血管发生

2018-02-14 lishiting MedSci原创

牙髓中成牙本质分化、牙本质形成和血管发生的上调是活髓治疗的关键因素。这篇研究的目的是为了评估瘦素是否可以促进人牙髓细胞(hDPCs)的成牙本质分化和血管发生。另外,研究也探讨在这一过程中参与调控的信号通路。

牙髓中成牙本质分化、牙本质形成和血管发生的上调是活髓治疗的关键因素。这篇研究的目的是为了评估瘦素是否可以促进人牙髓细胞(hDPCs)的成牙本质分化和血管发生。另外,研究也探讨在这一过程中参与调控的信号通路。

研究通过水溶性四唑盐-1测定检测hDPCs施加瘦素后的活力。通过实时聚合酶链式反应检测成牙本质分化及血管发生标志物的信使RNA (mRNA)的表达水平变化。通过WB检测成牙本质分化和血管发生相关蛋白表达水平并评估胞外信号调节激酶通路的调控作用。在施加瘦素或/和MAPK抑制剂后,通过碱性磷酸酶(ALP)和茜素红染色评估ALP表达水平和钙化结节形成情况。

结果显示,本次研究所有浓度的瘦素都未明显影响hDPCs的活力。然而,与对照组相比,施加瘦素可以显著提高成牙本质分化和血管发生标志物mRNA和蛋白的表达水平,促进ALP活性及钙化结节的形成。施加瘦素5分钟会增强胞外信号相关激酶、c-Jun氨基末端激酶和p38 MAPK的磷酸化水平。然而,施加MAPK抑制剂会轻微抑制瘦素诱导的牙本质涎磷蛋白和血管内皮生长因子的蛋白表达以及矿化。

结论:瘦素通过激活MAPK信号通路诱导hDPCs的血管发生、成牙本质分化及矿化。

原始出处:

Ngo VA, Jung JY, et al. Leptin Induces Odontogenic Differentiation and Angiogenesis in Human Dental Pulp Cells via Activation of the Mitogen-activated Protein Kinase Signaling Pathway. J Endod. 2018 Jan 31. pii: S0099-2399(17)31263-3. doi: 10.1016/j.joen.2017.11.018.

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    2018-07-05 lidong51
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287896, encodeId=c94e28e89624, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 14 12:07:11 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-11-28 jxrzshh
  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287896, encodeId=c94e28e89624, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 14 12:07:11 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 changjiu

    学习一下休息

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287896, encodeId=c94e28e89624, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Feb 14 12:07:11 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 sodoo
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    2018-02-16 chengjn
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    2018-02-14 183****7028

    学习

    0

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评估慢性偏头痛(CM)患者牙周炎(CP)患病率及其对血清瘦素水平的影响。

Cell:揭示瘦素促进身体燃烧脂肪之谜

当食物稀少时,为了持续给人类的大脑供应能量,哺乳动物进化出从燃烧碳水化合物转换为燃烧脂肪的能力,以保存骨骼肌,不然这些骨骼肌经代谢后会转化为葡萄糖。

Metabolism:鸢尾素、瘦素浓度与肥胖和2型糖尿病之间的相关性分析!

由此可见,肥胖组瘦素浓度较高,无论糖耐量如何。空腹血糖受损的肥胖者较糖耐量正常的非肥胖者循环鸢尾素浓度较高。鸢尾素浓度并不能前瞻性地预测糖尿病发生风险。

PNAS:瘦素之外的脂肪稳态新机制

大家都会注意到,每天花费很长时间来静坐的人群肥胖的风险一般会有所增加,但是至今为止,关于减肥效果的机制尚不清楚。

J Clin Periodontol:瘦素作为生物标记物在牙周炎和慢性偏头疼间关系中的作用

这篇研究的目的是为了评估慢性偏头疼(CM)患者罹患牙周炎(CP)的流行趋势以及CP对CM血清瘦素水平的影响。