Am J Gastroenterol:腹部内脏肥胖可增加肠易激综合征患病风险

2015-01-15 lijiasu 译 MedSci原创

近日,韩国东国大学医学院Ilsan医院内科的研究人员进行了一项病例对照研究,发现腹部肥胖可增加肠易激综合征患病风险,最新研究成果在线发表于1月13日的Am J Gastroenterol杂志上。

目前有多项研究认为肥胖是各种低位胃肠道症状的危险因素。但是腹部内脏肥胖与肠易激综合征(IBS)发生率之间的关系尚未被研究清楚。


近日,韩国东国大学医学院Ilsan医院内科的研究人员进行了一项病例对照研究,发现腹部肥胖可增加肠易激综合征患病风险,最新研究成果在线发表于1月13日的Am J Gastroenterol杂志上。

这项研究比较了2012-01至2013-08期间在该院健康促进中心常规体检行腹部CT检查的肠易激综合征患者(IBS组)和健康对照受试者(非IBS组)的内脏脂肪组织面积。研究人员回顾性电话调查确认受试肠易激综合征患者符合Rome III诊断标准。该研究通过测量内脏脂肪组织(VAT)、皮下脂肪组织(SAT)、VAT/SAT比值、体重指数(BMI)和腰围(WC)等指标数据来评估肠易激综合征和腹部肥胖的关系。

研究结果显示,所有纳入研究的受试者肠易激综合征的总患病率为19.9%(67/336)。单变量分析显示,IBS组内脏脂肪组织面积、VAT/SAT比值、腰围、合并反流性食管炎和女性比例显著高于非IBS组。然而,较高的体重指数或皮下脂肪组织面积并不增加肠易激综合征患病风险。多变量分析显示,较高的内脏脂肪组织面积(比值比OR=9.42,,95%CI 2.90-30.64,P=0.001)、VAT/SAT比值(OR=10.15,95%CI 3.05-33.58,P=0.001)和腰围(OR=7.81,95%CI 2.13-28.66,P=0.002)与肠易激综合征患病风险独立相关。只有在IBS-D组,而不是IBS-C,腹部肥胖与增加的肠易激综合征患病风险密切相关。

这项病例对照研究认为,腹部肥胖,尤其是内脏脂肪组织(VAT)、VAT/SAT比值和腰围(WC)等测量指标数据,与增加的肠易激综合征患病风险密切相关,尤其是IBS-D亚型。然而,皮下脂肪组织(SAT)或体重指数(BMI)与增加的肠易激综合征患病风险关联不大。

原始出处:

Chang Geun Lee, Jun Kyu Lee, Yun-Seong Kang, et al.Visceral Abdominal Obesity Is Associated With an Increased Risk of Irritable Bowel Syndrome.Am J Gastroenterol, 13 Jan 2015, doi:10.1038/ajg.2014.422

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    2015-10-02 许安
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