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Exp Biol Med：人间充质干细胞在体外培养时存在自发性的肿瘤转化

2016-12-13 生物谷 生物谷

人间充质干细胞肿瘤转化
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在一项新的研究中，来自荷兰伊拉兹马斯大学鹿特丹医学中心的Qiuwei Pan博士、Luc van der Laan博士和同事们发现人间充质干细胞(mesenchymal stem/stromal cells, MSCs)的自发性肿瘤转化(tumorigenic transformation)能够在体外细胞增殖期间发生，不过这种转化频率相对较低，通常只有在体外大量传代培养时才能观察到。相关研究结果近


在一项新的研究中，来自荷兰伊拉兹马斯大学鹿特丹医学中心的Qiuwei Pan博士、Luc van der Laan博士和同事们发现人间充质干细胞(mesenchymal stem/stromal cells, MSCs)的自发性肿瘤转化(tumorigenic transformation)能够在体外细胞增殖期间发生，不过这种转化频率相对较低，通常只有在体外大量传代培养时才能观察到。相关研究结果近期发表在Experimental Biology and Medicine期刊上，论文标题为“Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells”。

当前，科学家们正在广泛地研究MSCs作为一种潜在的疗法用于治疗多种疾病。就细胞移植而言，MSCs通常是从病人或第三方供者体内分离出来的，然后在用于治疗之前在体外进行增殖。事实上，过去几十年以来，体外培养的初始细胞的自发性肿瘤转化已得到很好的研究。

最近，小鼠和猴子MSCs的恶性肿瘤转化也被报道过。

在当前的这项研究中，研究人员证实人MSCs的自发性肿瘤转化能够在体外细胞增殖期间发生。这潜在地对体外增殖的MSCs的临床应用带来重大影响。Pan博士强调道，“尽管这种转化较为罕见，但是我们确实需要在移植到病人体内之前，仔细地检查体外培养的MSCs中是否存在这些异常的细胞。如今，我们鉴定出RNA分子标志物，它们能够潜在地被用来检测体外长期培养的MSCs中这些危险的细胞。然而，还需进一步研究以便在用于临床试验的体外MSCs培养物中验证这种标志物。”

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    2017-11-19 ms9651749636653578

    #体外培养#

    0

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    2017-08-13 h.y200607_23674418

    #间充质干细#

    0

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    2017-02-20 12498ebem31暂无昵称

    #Biol#

    0

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    2017-02-05 sunylz

    #Bio#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1946187, encodeId=f731194618e9c, content=<a href='/topic/show?id=243f265460f' target=_blank style='color:#2F92EE;'>#体外培养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26546, encryptionId=243f265460f, topicName=体外培养)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/6238544484D1FE65CCBBD849EAEE67C2/100, createdBy=47102500004, createdName=ms9651749636653578, createdTime=Sun Nov 19 11:14:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815250, encodeId=507c181525090, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 13 15:14:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767057, encodeId=bcdf1e67057c7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Feb 20 09:14:00 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917350, encodeId=50c7191e3508f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Feb 05 10:14:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530536, encodeId=532b153053668, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607215, encodeId=78c4160e21593, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162501, encodeId=84e51625011f, content=今后的发展方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Tue Dec 13 16:31:42 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-15 sodoo

    #自发性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1946187, encodeId=f731194618e9c, content=<a href='/topic/show?id=243f265460f' target=_blank style='color:#2F92EE;'>#体外培养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26546, encryptionId=243f265460f, topicName=体外培养)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/6238544484D1FE65CCBBD849EAEE67C2/100, createdBy=47102500004, createdName=ms9651749636653578, createdTime=Sun Nov 19 11:14:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815250, encodeId=507c181525090, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 13 15:14:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767057, encodeId=bcdf1e67057c7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Feb 20 09:14:00 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917350, encodeId=50c7191e3508f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Feb 05 10:14:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530536, encodeId=532b153053668, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607215, encodeId=78c4160e21593, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162501, encodeId=84e51625011f, content=今后的发展方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Tue Dec 13 16:31:42 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-15 ms3994565386320060

    #Med#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1946187, encodeId=f731194618e9c, content=<a href='/topic/show?id=243f265460f' target=_blank style='color:#2F92EE;'>#体外培养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26546, encryptionId=243f265460f, topicName=体外培养)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/6238544484D1FE65CCBBD849EAEE67C2/100, createdBy=47102500004, createdName=ms9651749636653578, createdTime=Sun Nov 19 11:14:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815250, encodeId=507c181525090, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 13 15:14:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767057, encodeId=bcdf1e67057c7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Feb 20 09:14:00 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917350, encodeId=50c7191e3508f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Feb 05 10:14:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530536, encodeId=532b153053668, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607215, encodeId=78c4160e21593, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 15 02:14:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162501, encodeId=84e51625011f, content=今后的发展方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Tue Dec 13 16:31:42 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-13 杨帆7792

    今后的发展方向

    0