BMJ:AbC-19快速免疫分析法用于新冠肺炎筛查的准确性研究

2020-11-14 MedSci原创 MedSci原创

由于光谱偏差,AbC-19快速侧流免疫分析法用于新冠肺炎感染人群筛查的敏感性低于PCR,其假阳性率可能超过20%

常规的新冠肺炎核酸检测方法需24小时,近日研究人员评价了AbC-19快速侧流免疫分析检测法用于新冠状病毒 (SARS-CoV-2)感染筛查的准确性。
 
本次研究为基于实验室的评估,2020年6月,英格兰2847名特殊岗位工作人员,如医护人员、消防和救援人员以及警察参与研究,其中268名先前的聚合酶链反应(PCR)结果呈阳性(中位数为63天),2579名未知,1995名在新冠大流行前献过血。研究的主要终点为AbC-19检测的敏感性和特异性,以已知阴性(大流行前)和已知阳性(PCR证实)样本为主要参考标准,使用罗氏电子抗核蛋白分析法(一种高度敏感的实验室免疫分析法),作为次要参考标准。
 
由于阳性显色带光谱结果较弱,AbC-19测试结果的判断存在一定的主观性,3名经过先前培训的实验人员对结果的判断存在一定差异。对于同一名测试人员,对于已知的阳性和阴性样本,AbC-19测试法的敏感性为92.5%,特异性为97.9%。采用免疫分析法作为参考标准,PCR确诊病例的敏感性为94.2%,但抗体阳性人群的敏感性仅84.7%。AbC-19测试法在抗体浓度较高时敏感性较高,而只有62%(218/354)的血清抗体阳性人群有症状。模型研究认为,对100万名特殊岗位人群进行AbC-19检测,假设10%的实际感染人群,预计真阳性人群为84700例,假阳性结果18900例,阳性结果正确的概率为81.7%。
 
研究认为,由于光谱偏差,AbC-19快速侧流免疫分析法用于新冠肺炎感染人群筛查的敏感性低于PCR,其假阳性率可能超过20%。
 
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    2021-04-26 gaoxiaoe
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    2020-11-14 12582d2fm84暂无昵称

    好的

    0

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    2020-11-14 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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