GC & GPC:胃肠道菌群与中医药干预

2022-06-23 August MedSci原创

近年来的研究表明,胃肠道菌群失衡与胃癌(GC)和癌前病变之间存在潜在关系。因此,恢复胃肠道菌群平衡具有重要意义。

胃癌 (GC) 的发病率和死亡率不断上升,已成为全球健康威胁。在胃癌的病理演变过程中,萎缩、肠化生、假幽门腺化生、异型增生被视为胃癌前病变(GPC)或胃癌癌前病变(PLGC),这代表了预防 GC 的有效干预阶段。随着微生态学的发展,GC和GPC的研究转向了胃肠道菌群,并取得了一些进展。此外,中药(TCM)的应用在相关临床试验中取得了良好的效果。此文就胃肠道菌群的主要组成和分布、影响因素、胃肠道菌群与GC、GPC的关系以及中医药在胃癌防治中的干预等方面进行简要综述,旨在为胃癌防治提供新的思路,更好的临床服务。

胃肠道菌群的主要组成及分布:

影响胃肠道微生态的因素(PPI:质子泵抑制剂;H2RI:H2受体抑制剂;Hp:幽门螺杆菌):

胃微生物区系与GC和GPC的关系:

与 GC 和 GPC 相关的胃肠道微生物群落:

肠道益生菌通过调节免疫力来保护粘膜屏障(DC:树突状细胞;NK:自然杀伤细胞):

通过胃肠道菌群的代谢提高中药(TCM)的疗效:

综上所述,慢性炎症恶化为GC和GPC是一个涉及多个因素和步骤的长期过程。许多胃肠道微生物群落于体内,起到促进消化吸收、维持消化系统生理功能的作用。分子检测技术和生物学分析的发展拓宽了对胃肠道菌群的认知,对胃癌等胃病的病理机制进行了重新思考。随着研究的深入,发现胃肠道菌群与GC、GPC之间存在一定的关系。中药对胃肠道菌群具有双向调节作用,可有效预防癌变。

原文:Yuan B. Chinese Medicine, Which Targets Body's Response State, Is An Effective Way to Treat Epidemic Infectious Diseases. Chin J Integr Med. 2022 Feb;28(2):168-175. doi: 10.1007/s11655-020-3324-z. Epub 2020 Oct 10. PMID: 33044601; PMCID: PMC7548526.

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    2022-06-17 cathymary

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