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子宫内膜异位症相关疼痛：GnRH受体拮抗剂linzagolix的II期试验取得成功

2019-05-05 不详 网络

GnRH受体拮抗剂linzagolix子宫内膜异位症
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ObsEva是一家临床阶段的生物制药公司，致力于开发用于治疗女性生殖疾病的新疗法，ObsEva近日报道了IIb期EDELWEISS试验的后续结果，证明了口服促性腺激素释放激素（GnRH）受体拮抗剂linzagolix用于治疗子宫内膜异位症相关的骨盆疼痛的有效性。

ObsEva是一家临床阶段的生物制药公司，致力于开发用于治疗女性生殖疾病的新疗法，ObsEva近日报道了IIb期EDELWEISS试验的后续结果，证明了口服促性腺激素释放激素（GnRH）受体拮抗剂linzagolix用于治疗子宫内膜异位症相关的骨盆疼痛的有效性。这些新数据包括28周延长研究治疗（即连续治疗52周）以及24周治疗后的随访结果（这些患者在完成最初的24周后未进入延伸研究治疗期）。

ObsEva联合创始人兼首席执行官Ernest Loumaye说：“该试验显示，在使用linzagolix治疗52周的患者中，75mg或200mg剂量组患者均能够维持盆腔疼痛的低反应率，骨矿物质密度保持在安全限度内。治疗完成后随访6个月的患者的疼痛得到持续控制，并显示骨密度增加。这些数据进一步支持了linzagolix的长期治疗潜力。我们预计在今年晚些时候将从子宫肌瘤的试验中获得初步的III期临床结果”。


原始出处：

http://www.firstwordpharma.com/node/1638464?tsid=4#axzz5mwpWeWX8

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    2019-12-15 ms5187542471278033

    #II期试验#

    0

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    2020-02-03 夏天与十三菇凉

    #GnRH#

    0

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    2019-06-12 12498974m61暂无昵称

    #内膜#

    0

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    2019-11-26 siiner

    #linzagolix#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1947716, encodeId=c7bf194e71680, content=<a href='/topic/show?id=24ef96066d' target=_blank style='color:#2F92EE;'>#II期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9606, encryptionId=24ef96066d, topicName=II期试验)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Dec 15 16:02:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763331, encodeId=e1eb1e6333163, content=<a href='/topic/show?id=830281465d' target=_blank style='color:#2F92EE;'>#GnRH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8146, encryptionId=830281465d, topicName=GnRH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4da137488682, createdName=夏天与十三菇凉, createdTime=Mon Feb 03 16:02:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708519, encodeId=20911e0851920, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Jun 12 07:02:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947675, encodeId=fa6b194e675bb, content=<a href='/topic/show?id=14d3109148e' target=_blank style='color:#2F92EE;'>#linzagolix#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10914, encryptionId=14d3109148e, topicName=linzagolix)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Tue Nov 26 11:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665649, encodeId=531116656491f, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Mon May 13 10:02:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036944, encodeId=b8b120369441b, content=<a href='/topic/show?id=9586814837' target=_blank style='color:#2F92EE;'>#GnRH受体拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8148, encryptionId=9586814837, topicName=GnRH受体拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Tue Nov 26 10:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511728, encodeId=ee9c1511e2805, content=<a href='/topic/show?id=90d75628960' target=_blank style='color:#2F92EE;'>#拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56289, encryptionId=90d75628960, topicName=拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474c10379153, createdName=ms5236388012055669, createdTime=Tue May 07 09:02:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
    2019-05-13 12498f17m74暂无昵称

    #子宫内膜异位#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1947716, encodeId=c7bf194e71680, content=<a href='/topic/show?id=24ef96066d' target=_blank style='color:#2F92EE;'>#II期试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9606, encryptionId=24ef96066d, topicName=II期试验)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Dec 15 16:02:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763331, encodeId=e1eb1e6333163, content=<a href='/topic/show?id=830281465d' target=_blank style='color:#2F92EE;'>#GnRH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8146, encryptionId=830281465d, topicName=GnRH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4da137488682, createdName=夏天与十三菇凉, createdTime=Mon Feb 03 16:02:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708519, encodeId=20911e0851920, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Jun 12 07:02:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947675, encodeId=fa6b194e675bb, content=<a href='/topic/show?id=14d3109148e' target=_blank style='color:#2F92EE;'>#linzagolix#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10914, encryptionId=14d3109148e, topicName=linzagolix)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/385F510BDFE0F55A4FFDFDFFD9892943/100, createdBy=a3262500163, createdName=siiner, createdTime=Tue Nov 26 11:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665649, encodeId=531116656491f, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Mon May 13 10:02:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036944, encodeId=b8b120369441b, content=<a href='/topic/show?id=9586814837' target=_blank style='color:#2F92EE;'>#GnRH受体拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8148, encryptionId=9586814837, topicName=GnRH受体拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Tue Nov 26 10:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511728, encodeId=ee9c1511e2805, content=<a href='/topic/show?id=90d75628960' target=_blank style='color:#2F92EE;'>#拮抗剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56289, encryptionId=90d75628960, topicName=拮抗剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474c10379153, createdName=ms5236388012055669, createdTime=Tue May 07 09:02:00 CST 2019, time=2019-05-07, status=1, ipAttribution=)]
    2019-11-26 风铃821

    #GnRH受体拮抗剂#

    0

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    2019-05-07 ms5236388012055669

    #拮抗剂#

    0