Medicine:右美托咪定在膝关节镜手术疼痛管理中的应用:系统评价与Meta分析

2017-11-15 田磊 “罂粟花”微信号

背景与目的:右美托咪定在膝关节镜手术患者疼痛控制中具有一定的潜在优势。为了解右旋美托咪啶在膝关节镜手术患者中的疗效,我们进行了这项系统评价和Meta分析

背景与目的:右美托咪定在膝关节镜手术患者疼痛控制中具有一定的潜在优势。为了解右旋美托咪啶在膝关节镜手术患者中的疗效,我们进行了这项系统评价和Meta分析

方  法:我们在PubMed、Embase、Web of Science、EBSCO、Cochrane图书馆数据库搜索了关于右美托咪定对膝关节镜手术疗效评价的随机对照试验(RCTs) ,主要结局指标为疼痛评分。采用随机效应模型进行Meta分析

结  果:最终纳入5项RCTs。总体而言,与膝关节镜手术患者相比,右美托咪定可显着降低疼痛评分(均值标准差= -0.84; 95% CI= -1.24 to -0.44; P <0.0001)和术后双氯芬酸钠用量(均值标准差= -1.76; 95% CI= -3.32 to -0.21; P=0.03),提高镇痛效果的持续时间(均值标准差= 1.78; 95% CI= 0.56-3.00; P=0.004),但对低血压(危险比RR= 0.93; 95%CI = 0.14-5.92; P =0.94)、心动过缓(RR=4.93; 95% CI=0.91-26.58; P=0.06)、恶心呕吐(RR=1.96; 95% CI=0.31-12.58; P=0.48)的发生无影响。

结  论:右美托咪定干预能显着降低疼痛评分和术后双氯芬酸钠用量并提高膝关节镜手术患者镇痛效果的持续时间,但对低血压、心动过缓、恶心呕吐的发生没有影响

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    2018-02-08 一闲
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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-12-29 jeanqiuqiu
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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1896203, encodeId=db16189620337, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Feb 08 15:04:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042513, encodeId=bade204251310, content=<a href='/topic/show?id=ccb48588183' target=_blank style='color:#2F92EE;'>#膝关节镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85881, encryptionId=ccb48588183, topicName=膝关节镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, 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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
  6. 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content=<a href='/topic/show?id=9cd3301521d' target=_blank style='color:#2F92EE;'>#关节镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30152, encryptionId=9cd3301521d, topicName=关节镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7693435830, createdName=xzw114, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444292, encodeId=a932144429274, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-23 kalseyzl
  7. 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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-12-31 guojianrong
  8. [GetPortalCommentsPageByObjectIdResponse(id=1896203, encodeId=db16189620337, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Feb 08 15:04:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042513, encodeId=bade204251310, content=<a href='/topic/show?id=ccb48588183' target=_blank style='color:#2F92EE;'>#膝关节镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85881, encryptionId=ccb48588183, topicName=膝关节镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, 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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-17 xzw114
  9. 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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-17 huagfeg
  10. 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time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577577, encodeId=864915e757764, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri Nov 17 01:04:00 CST 2017, time=2017-11-17, status=1, ipAttribution=)]