BMC Gastroenterology:标准和改良肠道准备在成人囊性纤维化患者中行结肠镜检查时的疗效比较

2019-06-26 不详 MedSci原创

据报道,患有囊性纤维化(CF)的成人患结直肠癌(CRC)的风险是一般人群的5到10倍。在本项研究中,研究人员比较了两种肠道准备方案,标准肠道准备和改良的CF肠道准备在患者行结肠镜检查中的疗效差别。

背景
据报道,患有囊性纤维化(CF)的成人患直肠癌(CRC)的风险是一般人群的5到10倍。在本项研究中,研究人员比较了两种肠道准备方案,标准肠道准备和改良的CF肠道准备在患者行结肠镜检查中的疗效差别。

方法
研究人员对2001年至2015年期间,485名就诊的CF患者进行了回顾性分析; 70名CF患者进行了初步的结肠镜检查,并对其中27名患者开出标准肠道准备,并对38名患者进行改良CF肠道准备。

结果
在肠道可视化结果中,改良CF肠道准备组和标准肠道准备组之间存在显着差异,改良CF肠道准备组具有更高比例的“优异/良好”GI可视化清洁程度(50.0% VS 25.9%),“差”可视化清洁率(10.5% VS 44.5%)(p= 0.006)。两组的“公平”GI清洁可视化率相似(39.4% VS 29.6%)。初始结肠镜检查中腺瘤性息肉的检出率在改良CF肠道准备组中高于标准制剂组(50.0% VS 18.5%,p <0.01)。患者年龄> 40岁的阳性腺瘤性息肉检出率高于<40岁的患者(40.5%VS 24.3%)(p= 0.003)。两组的结肠腺癌诊断相似。

结论
该研究结果表明标准肠道准备在CF患者的结肠镜检查中通常是不充分的,并且需要使用改良CF肠道准备的结肠灌洗来获得良好的结肠可视化。40岁以上(相对于40岁以下)患者的息肉发生率较高是明显的。

原始出处:

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    2019-07-29 许安
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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Jul 29 03:02:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711981, encodeId=46a51e11981e1, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Nov 16 23:02:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675905, encodeId=6f2f16e590546, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, 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target=_blank style='color:#2F92EE;'>#囊性纤维化患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40381, encryptionId=a5c54038142, topicName=囊性纤维化患者)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/17F844FBE270B8196CB4C53EC9493C57/100, createdBy=9d712500079, createdName=ms5906905816781247, createdTime=Tue Aug 27 02:02:00 CST 2019, time=2019-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434487, encodeId=1720143448e02, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#肠道准备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81657, encryptionId=9e148165ed6, topicName=肠道准备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0f814152129, createdName=wjcjjian, createdTime=Fri Jun 28 05:02:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032204, encodeId=ae16103220478, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Jun 26 17:02:00 CST 2019, time=2019-06-26, status=1, ipAttribution=)]
    2020-01-03 wolongzxh
  5. 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style='color:#2F92EE;'>#肠道准备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81657, encryptionId=9e148165ed6, topicName=肠道准备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0f814152129, createdName=wjcjjian, createdTime=Fri Jun 28 05:02:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032204, encodeId=ae16103220478, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Jun 26 17:02:00 CST 2019, time=2019-06-26, status=1, ipAttribution=)]
  6. 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target=_blank style='color:#2F92EE;'>#囊性纤维化患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40381, encryptionId=a5c54038142, topicName=囊性纤维化患者)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/17F844FBE270B8196CB4C53EC9493C57/100, createdBy=9d712500079, createdName=ms5906905816781247, createdTime=Tue Aug 27 02:02:00 CST 2019, time=2019-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434487, encodeId=1720143448e02, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, 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  7. 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style='color:#2F92EE;'>#肠道准备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81657, encryptionId=9e148165ed6, topicName=肠道准备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0f814152129, createdName=wjcjjian, createdTime=Fri Jun 28 05:02:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032204, encodeId=ae16103220478, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Jun 26 17:02:00 CST 2019, time=2019-06-26, status=1, ipAttribution=)]
    2019-06-28 zhouqu_8
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    2019-06-26 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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炎症性肠病患者长期带病生存后有患结直肠肿瘤的风险,本研究旨在评估中国炎症性肠病(IBD)患者结肠炎相关瘤形成(CAN)发生的危险因素。

Dig Liver Dis: 肠粘膜相关微生物群比粪便微生物群更好地揭示了炎症性肠病的模式差异

越来越多的证据表明肠道微生物群在炎症性肠病(IBD)的病理生理学中发挥着潜在作用。本研究的目的是评估IBD患者与健康对照(CTRL)相比的粘膜(MM)和粪便微生物群(FM)组成成分差异。

Dig Dis Sci:肠易激综合征中的腹胀严重程度与心理因素和合并症相关

腹胀是肠易激综合征(IBS)中最令人烦恼的症状之一,但其与其他症状的关联尚未得到很好的描述。因此,本项研究旨在探究肠易激综合征造成的腹胀与心理困扰和共病症状之间的关联。

JCC:中性粒细胞胞外网状结构维持溃疡性结肠炎的炎症

在溃疡性结肠炎[UC]中,粘膜损伤发生在浸润有中性粒细胞的区域。中性粒细胞的抗微生物功能部分依赖于细胞外网状结构的形成,称为中性粒细胞胞外网[NETs]。异常的NET的形成和/或清除与几种免疫疾病有关。本项研究旨在调查NETs在UC相关炎症中的作用。

Dig Dis Sci:肥胖症会增加患有艰难梭菌感染的炎症性肠病患者结肠切除术风险

肥胖和炎症性肠病(IBD)与艰难梭菌感染(CDI)的风险增加有关。因此,研究人员进行了这项研究,以检查肥胖对住院IBD患者CDI相关发病率和死亡率的影响。

Dig Liver Dis: 影响IBD患者维生素D缺乏的因素分析

维生素D缺乏症在炎性肠病(IBD)中普遍存在,并且可能与疾病活动有关。因此,本研究评估了意大利IBD患者队列中的维生素D(VitD)状态,并调查了VitD缺乏的危险因素及其与疾病活动的相关性。