Circulation:次要动脉(桡动脉)导管移植可明显改善进行多支冠脉搭桥术患者的预后!

2018-04-21 MedSci MedSci原创

次要动脉导管是否可改善多条冠状动脉旁路移植术的预后尚不明确。因此,在美国,除了左侧胸腔内动脉以外的动脉导管很少使用。研究人员在加利福尼亚的126家非联邦医院开展一项临床试验,收集2006-2011年间用左侧胸内动脉进行初次、孤立的多支冠状动脉搭桥的患者数据,对比同时进行次要动脉导管(又胸内动脉或桡动脉)搭桥(5866人)或静脉导管搭桥(53566人)的倾向性评分匹配的患者队列的所有原因的死亡和中风

次要动脉导管是否可改善多条冠状动脉旁路移植术的预后尚不明确。因此,在美国,除了左侧胸腔内动脉以外的动脉导管很少使用。

研究人员在加利福尼亚的126家非联邦医院开展一项临床试验,收集2006-2011年间用左侧胸内动脉进行初次、孤立的多支冠状动脉搭桥的患者数据,对比同时进行次要动脉导管(又胸内动脉或桡动脉)搭桥(5866人)或静脉导管搭桥(53566人)的倾向性评分匹配的患者队列的所有原因的死亡和中风、心肌梗死、重复血管搭桥和胸部切口感染的概率。通过34个术前特征进行倾向性评分,共获得5813对匹配组。并进行一亚组分析,对比右胸内动脉(1576人)和桡动脉(4290人)移植受体的预后。

次要动脉导管使用量从2006年10.7%下降至2011年的9.1%(p<0.0001)。但是,进行次要动脉导管移植患者的死亡率明显降低(7年死亡率:13.1% vs 10.6%;危险比 0.79;95% CI 0.72-0.87),心肌梗死(危险比 0.78;95% CI 0.70-0.87)和重复血管搭桥(危险比 0.82;95% CI 0.76-0.88)的风险也降低。与桡动脉移植相比,右胸动脉移植的死亡率相近(7年死亡率:右胸动脉 10.3% vs 桡动脉 10.7%;危险比 1.10;95% CI 0.89-1.37),个体心血管意外风险也相近,但胸部切口感染的风险增加(风险差 1.07%;95% CI 0.15-2.07)。

加利福尼亚采用次要动脉导管移植的比例低,而且在持续降低,但动脉移植可显著降低患者的死亡率、减少心血管意外。右侧胸动脉移植相比桡动脉移植无更多效益,而且会增加胸部切口感染的风险。本研究结果提示外科医生应考虑放宽进行动脉移植的标准,而桡动脉可能是次要动脉导管移植的首选。

原始出处:

Andrew B. Goldstone,et al.Second Arterial Versus Venous Conduits for Multivessel Coronary Artery Bypass Surgery in California.Circulation. April 17,2018. https://doi.org/10.1161/CIRCULATIONAHA.117.030959

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    2018-04-23 zzc2214
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    2018-04-23 yese
  6. [GetPortalCommentsPageByObjectIdResponse(id=1682078, encodeId=3e7c16820e8ec, content=<a href='/topic/show?id=202b309688b' target=_blank style='color:#2F92EE;'>#冠脉搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30968, encryptionId=202b309688b, topicName=冠脉搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41e27933971, createdName=ZGMFX33A, createdTime=Fri Jan 18 01:32:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663921, encodeId=42511663921fc, content=<a href='/topic/show?id=03a35691e2e' target=_blank style='color:#2F92EE;'>#搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56917, encryptionId=03a35691e2e, topicName=搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=557f25711234, createdName=12498b3em16(暂无昵称), createdTime=Tue Feb 26 10:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441101, encodeId=22af1441101d3, content=<a href='/topic/show?id=81a3623569c' target=_blank style='color:#2F92EE;'>#桡动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62356, encryptionId=81a3623569c, topicName=桡动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae384789560, createdName=12498aa2m63(暂无昵称), createdTime=Mon Apr 23 08:32:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492368, encodeId=18fa149236800, content=<a href='/topic/show?id=a251569194f' target=_blank style='color:#2F92EE;'>#搭桥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56919, encryptionId=a251569194f, topicName=搭桥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a28924986, createdName=zzc2214, createdTime=Mon Apr 23 08:32:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552911, encodeId=c4861552911a7, content=<a href='/topic/show?id=696730966a0' target=_blank style='color:#2F92EE;'>#冠脉搭桥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30966, encryptionId=696730966a0, topicName=冠脉搭桥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=710114309336, createdName=yese, createdTime=Mon Apr 23 08:32:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307992, encodeId=211830e99247, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Apr 21 22:47:26 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 大爰

    学习了谢谢分享!!

    0