Am J Hematol:抗体水平对血栓相关的原发性抗磷脂综合征患者的免疫系统的影响较大

2017-08-22 MedSci MedSci原创

抗磷脂抗体综合征(antiphospholipid syndrome,APS)是指由抗磷脂抗体(antiphospholipid antibody,APL抗体)引起的一组临床征象的总称。APL抗体是一组能与多种含有磷脂结构的抗原物质发生免疫反应的抗体,主要有狼疮抗凝物(lupus anti-coagulant,LA)、抗心磷脂抗体(anti-cardiolipid antibody,ACL抗体)、

抗磷脂抗体综合征(antiphospholipid syndrome,APS)是指由抗磷脂抗体(antiphospholipid antibody,APL抗体)引起的一组临床征象的总称。APL抗体是一组能与多种含有磷脂结构的抗原物质发生免疫反应的抗体,主要有狼疮抗凝物(lupus anti-coagulant,LA)、抗心磷脂抗体(anti-cardiolipid antibody,ACL抗体)、抗磷脂酸抗体和抗磷脂酰丝氨酸抗体等。与APL抗体有关的临床表现,主要为血栓形成、习惯性流产、血小板减少和神经精神症状等。抗磷脂抗体(antiphospholipid antibodies,APL抗体)三阳性(Triple positivity,TP)可以识别APL抗体携带者的较差预后。在原发性抗磷脂抗体综合征(primary antiphospholipid syndrome,PAPS)患者中TP的临床影响仍不清楚,需要进一步的临床研究来验证TP是其严重程度的一个标志。本研究的目的是探讨TP对有血栓形成的PAPS患者(t-PAPS)的临床过程的影响。这是一项回顾性分析,研究人员对一个t-PAP

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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-25 lou.minghong

    学习了谢谢分享!

    0

  3. 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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-23 fengyi812
  4. 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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 执着追梦

    学习.谢谢分享

    0

  6. 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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 李东泽

    很好.不错.以后会多学习

    0

  7. 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encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Aug 23 15:39:00 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235944, encodeId=c1f223594420, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Tue Aug 22 08:03:25 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235929, encodeId=152e2359296f, content=很好.不错.以后会多学习, 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GetPortalCommentsPageByObjectIdResponse(id=235904, encodeId=6aa32359040d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Tue Aug 22 07:17:58 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235889, encodeId=b46a23588982, content=平均随访观察患者有3.7年, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 明月清辉

    谢谢分享.学习

    0

  8. 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encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Aug 23 15:39:00 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235944, encodeId=c1f223594420, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Tue Aug 22 08:03:25 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235929, encodeId=152e2359296f, content=很好.不错.以后会多学习, 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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 榄枷檬

    谢谢分享

    0

  9. 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createdTime=Tue Aug 22 06:50:29 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235886, encodeId=f556235886bb, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Tue Aug 22 06:35:53 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 雾夜芭蕾

    平均随访观察患者有3.7年

    0

  10. 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