Journal of Nuclear Medicine:  18F-FDG PET / CT可发现尿道腺癌转移,指导分期和患者管理的改变

2021-05-13 MedSci原创 MedSci原创

18F-FDG PET/CT在UrC-ADC患者中具有临床实用价值,可识别解剖成像无法识别的转移性疾病,指导分期和患者管理的改变。

尿道腺癌(UrC-ADC)是一种侵袭性尿道非移行上皮肿瘤,是连接尿囊和胎儿膀胱的胚胎结构的残余。20%-50%的UrC-ADC患者有转移。UrC-ADC的分期是最重要的预后因素,I、II、III和IV期的5年生存率分别为63%、55%、19%和8%。因此,准确有效的分期是评估UrC-ADC和指导治疗的关键。

尽管18F-FDG PET/CT在许多恶性肿瘤中显示了价值,但组织学上UrC-ADC常呈粘液样,粘液性恶性肿瘤可能显示18F-FDG摄取低或缺失。因此,18F-FDG PET/CT可能对UrC-ADC不敏感。UrC-ADC中18F-FDG PET/CT的数据仅限于简短的报告和图片文章。Jeeban P. Das等的研究的目的是确定18F-FDG PET/CT是否影响UrC-ADC的全身分期及其临床管理

Jeeban P. Das等对凯特琳癌症中心2001年至2019年的UrC-ADC患者进行回顾性分析。测定18F -FDG PET / CT检查前梅奥分期,18F -FDG PET / CT检测到主要恶性肿瘤和转移的比例, 18F -FDG PET / CT检查后梅奥分期,以及患者管理变化。

筛查并纳入分析的患者的标准图解

共有21例URC-ADC患者,18F -FDG PET / CT检查前,8例为梅奥I / II期,3例III期、10例IV期。21例患者中,18F-FDG PET/CT检测到8(38%)先前未被确认的转移,导致3(14%)患者的分期等级增高,4(19%)患者的治疗改变。

一名患有UrC-ADC的50岁男性。轴位18F-FDG PET/CT (A)示肝脏病灶(箭头),SUVmax为9.0,之前增强CT未见病灶(B)。随后超声引导下对病灶活检,证实为转移。

47岁男性UrC-ADC。轴位PET/CT (A)示18F-FDG-avid胰腺病灶(箭头),SUVmax为14.2,另外腹部和骨盆增强CT造影未发现骨转移病灶(箭头)(B)。随后行细针穿刺内镜超声采集胰腺病灶,证实为转移。

该研究评估了18F-FDG PET/CT在UrC-ADC分期中的临床应用价值。相比于在术前6周内进行的横断面成像,18F-FDG PET/CT在近40%的患者中发现了额外的转移,而根据放射学标准,在近15%的患者中发现了晚期疾病。此外,18F-FDG PET/CT使得近20%患者管理或治疗计划的改变。

综上所述,18F-FDG PET/CT在UrC-ADC患者中具有临床实用价值,可识别解剖成像无法识别的转移性疾病,指导分期和患者管理的改变。

原文出处

Clinical Utility of 18F-FDG PET/CT for Staging and Treatment Planning in Urachal Adenocarcinoma. Jeeban P. Das, Hebert A. Vargas, Soleen Ghafoor, Alvin C. Goh, Gary A. Ulaner. Journal of Nuclear Medicine May 2021, 62 (5) 643-647; DOI: 10.2967/jnumed.120.251561

 

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    2022-01-17 lifestar
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    2022-02-07 kalseyzl
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    2021-08-16 xugumin
  4. [GetPortalCommentsPageByObjectIdResponse(id=1769182, encodeId=d8091e6918269, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Mon Jan 17 06:02:33 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773944, encodeId=72051e7394449, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Mon Feb 07 23:02:33 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024612, encodeId=663220246129b, content=<a href='/topic/show?id=5dc715e04b' target=_blank style='color:#2F92EE;'>#8F-FDG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1570, encryptionId=5dc715e04b, topicName=8F-FDG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Mon Aug 16 11:02:33 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859140, encodeId=b6d8185914090, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat May 22 09:02:33 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728944, encodeId=5e2f1e2894471, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 12 01:02:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331180, encodeId=225f1331180a2, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546038, encodeId=08df1546038fa, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577797, encodeId=984f15e779765, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590370, encodeId=665115903e005, content=<a href='/topic/show?id=2c17e154824' target=_blank style='color:#2F92EE;'>#癌转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71548, encryptionId=2c17e154824, topicName=癌转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dc017794099, createdName=linagood, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611046, encodeId=fab2161104628, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=)]
    2021-05-22 jeanqiuqiu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1769182, encodeId=d8091e6918269, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Mon Jan 17 06:02:33 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773944, encodeId=72051e7394449, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Mon Feb 07 23:02:33 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024612, encodeId=663220246129b, content=<a href='/topic/show?id=5dc715e04b' target=_blank style='color:#2F92EE;'>#8F-FDG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1570, encryptionId=5dc715e04b, topicName=8F-FDG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Mon Aug 16 11:02:33 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859140, encodeId=b6d8185914090, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sat May 22 09:02:33 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728944, encodeId=5e2f1e2894471, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 12 01:02:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331180, encodeId=225f1331180a2, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546038, encodeId=08df1546038fa, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577797, encodeId=984f15e779765, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590370, encodeId=665115903e005, content=<a href='/topic/show?id=2c17e154824' target=_blank style='color:#2F92EE;'>#癌转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71548, encryptionId=2c17e154824, topicName=癌转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dc017794099, createdName=linagood, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611046, encodeId=fab2161104628, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=)]
    2021-07-12 feather89
  6. [GetPortalCommentsPageByObjectIdResponse(id=1769182, encodeId=d8091e6918269, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Mon Jan 17 06:02:33 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773944, encodeId=72051e7394449, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546038, encodeId=08df1546038fa, content=<a href='/topic/show?id=3e0453069aa' target=_blank style='color:#2F92EE;'>#患者管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53069, encryptionId=3e0453069aa, topicName=患者管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179213855182, createdName=ms7421025882867189, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577797, encodeId=984f15e779765, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590370, encodeId=665115903e005, content=<a href='/topic/show?id=2c17e154824' target=_blank style='color:#2F92EE;'>#癌转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71548, encryptionId=2c17e154824, topicName=癌转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dc017794099, createdName=linagood, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611046, encodeId=fab2161104628, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 14 15:02:33 CST 2021, time=2021-05-14, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1769182, encodeId=d8091e6918269, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Mon Jan 17 06:02:33 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773944, encodeId=72051e7394449, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, 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    2021-05-14 智慧医人

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前列腺癌(PCa)是男性恶性肿瘤致死的第二位死因,转移是PCa患者死亡的主要原因。微RNAs(miRNAs)在肿瘤的发展和转移中起着重要的调控作用。

Oncogene:ApoC1能够促进透明细胞肾细胞癌的转移

透明细胞肾细胞癌(ccRCC)是最常见的肾癌,且诊断经常为晚期。即使经过适当的治疗,也容易发生不可预测的转移。抗血管生成治疗是转移性ccRCC最有效的治疗方法。因此,探索抑制血管生成和转移的新方法有可

Cancer Gene Therapy:CHD1缺失对R0切除的前列腺癌患者的无转移生存产生负面影响并促进体内自发转移

前列腺癌(PCa)患者的治疗结果变化很大,取决于是否发生远处转移。多条染色体缺失与根治性前列腺切除术(RP)后的早期肿瘤标志物PSA复发(生化复发,BCR)有关,但其对远处转移形成的潜在作用在很大程度

Br J Cancer:肿瘤酸中毒与乳腺癌的转移潜力相关

乳腺癌是全球女性中癌症相关死亡的第二大主要原因。癌症的远端转移仍是主要的死亡原因。在过去的几年中,由于筛查程序和早期诊断的增加,乳腺癌患者的转移和死亡率有所降低。