Invest Radiol:晚期肾功能衰竭住院患者的放射线增强计算机断层扫描后的急性肾脏损伤

2020-05-04 MedSci原创 MedSci原创

计算机断层扫描(CT)术后发生对比剂急性肾损伤(PC-AKI)的总体风险可以忽略不计,这可能是因为所需注射的碘化造影剂量较小。然而,造影剂增强CT在晚期肾功能损害患者中的安全性尚不清楚,而这是PC-A

计算机断层扫描(CT)术后发生对比剂急性肾损伤(PC-AKI)的总体风险可以忽略不计,这可能是因为所需注射的碘化造影剂量较小。然而,造影剂增强CT在晚期肾功能损害患者中的安全性尚不清楚,而这是PC-AKI的主要危险因素。

 

这是一项回顾性研究,采用单一中心住院患者的大数据分析。纳入接受CT或磁共振成像的成人患者,并按估计肾小球滤过率(eGFR)(≤30或>30 mL/min/1.73 m)和造影增强或非造影增强分层。仅包括造影前后连续测定肌酐的患者。使用单变量分析、倾向性评分匹配和多变量logistic回归分析对组间人口统计学、临床和实验室数据进行了分析和比较。

 

共纳入了22,319项影像学研究。eGFR为30 mL/min/1.73 m或更低的患者发生PC-AKI的风险高于接受对比增强CT(n = 403)或非增强磁共振成像(n = 96)或非增强CT(n = 1576)或接受对比增强CT(n = 9173)的患者,其eGFR大于30 mL/min/1.73 m。这些研究结果在人口统计学、程序和临床参数的倾向性匹配后仍然如此。对所有接受CT成像前eGFR为30 mL/min或更低的患者(n = 1979)进行多变量回归分析,发现以碘为基础的造影剂增强使CT后AKI的可能性增加了51%(置信区间,1.23-2.05)。

 

尽管在大多数住院患者和门诊环境中,放射线增强CT被认为是安全的,但在住院患者中,有重大的影像学前肾功能损害的患者中,PC-AKI的风险仍然很高。在eGFR为30 mL/min/1.73 m或更低的住院患者,在使用碘增强CT时应谨慎。

 

原始出处:

 

Yuri GorelikNatalie Bloch-Isenberg,et al., Acute Kidney Injury After Radiocontrast-Enhanced Computerized Tomography in Hospitalized Patients With Advanced Renal Failure: A Propensity-Score-Matching Analysis. Invest Radiol. 2020 Feb 25. doi: 10.1097/RLI.0000000000000659. Online ahead of print.

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    2020-08-20 yese
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    2020-11-06 bioon14
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