PLOS ONE:酒精相关紧急入院增加自杀风险:280万人的队列研究

2018-04-30 海北 MedSci原创

酒精滥用是众所周知的自杀危险因素,但至今为止,酒精相关住院与随后死亡风险之间的关系尚不清楚。

酒精滥用是众所周知的自杀危险因素,但至今为止,酒精相关住院与随后死亡风险之间的关系尚不清楚。来自英国的研究人员进行了一项队列研究,目标是确定因酒精相关原因紧急入院后自杀死亡的风险。
研究人员于2006年1月1日为英国威尔士的2,803,457名居民建立了一项电子队列研究,居民年龄从10岁到100岁不等,随访6年。结局事件是自杀死亡,定义为故意自我伤害(ICD-10 X60-84)或未确定意图(Y10-34)。研究人员通过Cox回归对数据集内的混淆变量进行了调整。
在研究随访期间,有15,546,355人年数处于危险中,28,425例酒精相关紧急入院,1562例自杀。入院后有125人自杀(每100,000人年有144.6人),其中11人(9%)在出院后4周内自杀。入院后自杀的总调整风险比(HR)为26.8(95%置信区间(CI)18.8至38.3),男性HR 为9.83(95%CI 7.91至12.2),女性HR 为28.5(95%CI 19.9至41.0 )。
在没有共同存在的精神病的受试者中,自杀风险依然很大:男性HR为8.11(95%CI 6.30至10.4),女性HR为 24.0(95%CI 15.5至37.3)。该分析受限于数据集中缺乏可能重要的混杂变量以及缺乏关于未入院的受试者酒精相关伤害和精神病发病率的信息。
因此,该研究表明,与酒精相关的紧急入院与自杀风险增加有关。

原始出处:

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    2018-04-30 龙胆草

    学习谢谢分享

    0

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    2018-04-30 1ddf0692m34(暂无匿称)

    学习了.长知识

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    2018-04-30 wzb521zf

    一起学习学习

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    2018-04-30 wqkm

    ^_^^_^^_^

    0

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