Clin Oral Investig:牙齿蛀掉了,纳米羟基磷灰石能恢复吗?

2022-04-19 MedSci原创 MedSci原创

近年来,龋病的发病率逐渐下降,为加强龋病早期托矿区域的再矿化,研究人员开发了纳米羟基磷灰石(Ca10(PO4)3(OH)2)/碳酸锌-羟基磷灰石纳米晶体(nHA)。

近年来,龋病的发病率逐渐下降,为加强龋病早期托矿区域的再矿化,研究人员开发了纳米羟基磷灰石(Ca10(PO4)3(OH)2)/碳酸锌-羟基磷灰石纳米晶体(nHA)。该综述系统地探讨了调查纳米羟基磷灰石(nHA)对减少早期龋齿病变的发生或再矿化的功效的体内或原位研究。近日,发表于Clin Oral Investig的一项前瞻性对照(非)随机临床试验,调查了nHA与安慰剂治疗或未治疗/标准对照的疗效。

研究人员筛选了三个电子数据库(Central Cochrane, PubMed-MEDLINE, Ovid EMBASE)。结果内容包括如ICDAS评分、激光荧光、釉质再矿化率、矿物质流失和病变深度。使用偏倚风险2.0工具和GRADE分析器对偏倚风险和证据水平进行了分级。

 

结果,研究共纳入了5项体内(和5项原位)研究,包括至少有633颗牙齿(1031个标本),超过420(95)名患者。由于研究设计的高度异质性和结果的多样性,无法对体内研究进行meta分析。原位研究结果表明,在脱矿条件下,NaF能够阻碍牙齿脱矿,而nHA则不能;同时,nHA与无氟对照组的治疗结果没有区别。相反,在再矿化条件下,nHA和NaF显示出相同的再矿化潜力。然而,证据水平非常低。此外,有6项研究显示出较高的偏倚风险,而且有6项研究是由被测产品的制造商资助/发表的。

综上所述,该研究结果表明,目前关于nHA的临床研究数量少,随访时间短,偏倚风险高,证据等级有限,研究条件不能反映日常情况,因此不能说明nHA对提高再矿化或阻碍釉质龋齿脱矿的功效。

 

原始出处:

 

Richard Johannes Wierichs, et al., Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. Clin Oral Investig. 2022 Apr;26(4):3373-3381. doi: 10.1007/s00784-022-04390-4.

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    2022-10-16 小几洁
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    2022-07-25 ms5000001914377529

    学习了

    0

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    2022-04-26 1235bd28m70暂无昵称

    认真***

    0

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    2022-04-20 weigq

    学习

    0

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    2022-04-19 zhouqu_8
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