Clin Gastroenterlogy and Hepatology: 食管粘膜阻抗模式对GERD患者嗜酸细胞性食管炎患者的鉴别诊断有很大价值

2018-05-29 MedSci MedSci原创

由于嗜酸性食管炎症状和组织学特征与胃食管反流病(GERD)的重叠,因此诊断嗜酸性食管炎(EoE)是临床工作中一项挑战。最近研究人员开发了微创设备来检测粘膜阻抗(MI),其可在内窥镜检查期间测量上皮完整性。本项研究的目标是量化食管的MI,并确定患有和未患GERD的患者与EoE患者的差异

背景和目的
由于嗜酸性食管炎症状和组织学特征与胃食管反流病(GERD)的重叠,因此诊断嗜酸性食管炎(EoE)是临床工作中一项挑战。最近研究人员开发了微创设备来检测粘膜阻抗(MI),其可在内窥镜检查期间测量上皮完整性。本项研究的目标是量化食管的MI,并确定患有和未患GERD的患者与EoE患者的差异

方法
研究人员对91例上消化道症状患者进行了回顾性分析,所有患者来自于2012年至2014年的GERD和EoE诊断测试。在第一次内窥镜检查过程中,MI测量值是在距表皮柱交界处2,5和10 cm处获得的。GERD通过动态pH测试得到证实,活检组织学分析用于确认EoE。然后,我们使用统计学模型来识别食管(10 cm,5 cm和2 cm)与GERD和EoE相关的MI模式。研究人员在一项前瞻性队列研究中验证了我们的研究结果,这些患者从2015年到2016年接受了选择性上消化道内镜检查的49名患者,测试了鉴别EoE疾病的能力。

结果
我们发现EoE患者具有独特的粘膜阻抗模式,沿食管轴线的值较低。5cm处的MI测量可以辨别具有正常与异常粘膜的患者,具有83%的灵敏度和79%的特异性,并且具有84%灵敏度和70%特异性的EoE对GERD的患者。在验证研究中,评估者使用食管MI模式确定EoE患者的敏感性为100%,特异性为96%。

结论
我们确定并验证了沿食道的MI模式,该模式可以识别EoE与正常粘膜或GERD患者的差异,并进行鉴别诊断。

原始出处:

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    2019-04-29 许安
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    2018-07-11 guoyibin
  4. 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  5. 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  6. 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    2018-06-11 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu May 31 04:47:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462520, encodeId=238f14625205f, content=<a href='/topic/show?id=d627101081d8' target=_blank style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Thu May 31 04:47:00 CST 2018, time=2018-05-31, status=1, ipAttribution=)]
    2018-05-31 gwc384
  9. 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    2018-05-31 zhouqu_8
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