Sci Rep:新的研究揭示脂肪细胞分化的分子机制

2017-09-04 MedSci MedSci原创

脂肪细胞在调节全身能量平衡中的起着重要作用,且与肥胖有着密切的关联。既往许多研究都强调,microRNA在脂肪细胞分化过程中的相关性,但是关于长非编码RNAs(lncRNAs)在脂肪细胞分化过程中的作用仍是未知。本研究中,研究人员确定了lncRNA MIR31HG与脂肪细胞的相关性。体外和体内研究结果表明,敲除MIR31HG可抑制脂肪细胞的分化,而过表达MIR31HG可促进脂肪细胞的分化。此外,抑

脂肪细胞在调节全身能量平衡中的起着重要作用,且与肥胖有着密切的关联。既往许多研究都强调,microRNA在脂肪细胞分化过程中的相关性,但是关于长非编码RNAs(lncRNAs)在脂肪细胞分化过程中的作用仍是未知。

本研究中,研究人员确定了lncRNA MIR31HG与脂肪细胞的相关性。体外和体内研究结果表明,敲除MIR31HG可抑制脂肪细胞的分化,而过表达MIR31HG可促进脂肪细胞的分化。此外,抑制MIR31HG可减少活性组蛋白标记物、组蛋白H3赖氨酸4三甲基化(H3K4me3)和乙酰化(AcH3)、成脂相关基因的启动子及脂肪酸结合蛋白4(FABP4)的富集,导致其表达和成脂抑制。

总之,这些研究结果为脂肪细胞分化的分子机制提供了的新的见解,并表明MIR31HG可能参与了肥胖及相关疾病的发生。

原始出处:

Yiping Huang, Chanyuan Jin, et al., Knockdown of lncRNA MIR31HG inhibits adipocyte differentiation of human adipose-derived stem cells via histone modification of FABP4. Sci Rep. 2017; 7: 8080. Published online 2017 Aug 14. doi: 10.1038/s41598-017-08131-6.

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    2017-09-11 1e1263e3m20(暂无匿称)

    学习了多谢分享

    0

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    2017-09-10 lietome15

    认真学习.不断进步.把经验分享给同好.点赞了!

    0

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    2017-09-09 往日如昨

    继续学习中谢谢

    0

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    2017-09-09 往日如昨

    学习了谢谢分享

    0

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    2017-09-05 tanxingdoctor

    学习啦!谢谢分享!

    0

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    2017-09-04 惠映实验室

    学习了.谢谢.

    0

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近日,来自佛罗里达大学的一项新的研究显示,机体在运动时会释放一种激素——鸢尾素,这种激素不仅会帮助机体减掉脂肪还有助于预防脂肪的形成,该研究结果已发表于 American Journal of Physiology - Endocrinology and Metabolism。研究人员从25女性捐献者捐献的新鲜的皮下白色脂肪组织(scWAT)中获得人体脂肪细胞,以用来检验鸢尾素褐色脂肪和线粒体呼吸