Stroke:脑小血管病对颅内出血后功能恢复有何影响?

2020-03-01 shaosai MedSci原创

本研究旨在评价脑小血管病基于CT特征与颅内出血后神经功能及其恢复情况的相关性。

背景和目的
本研究旨在评价脑小血管病基于CT特征与颅内出血后神经功能及其恢复情况的相关性。
方法
本研究纳入了行CT检查的颅内出血患者,利用视觉等级量表评估脑白质疏松和脑萎缩的程度。不良神经功能结果定义为改良Rankin量表(mRS) ≥3。利用多远Logistic和线性回归模型评价脑小血管病影像学指标与出院时不良神经功能结果(出院时)和自出院后至脑卒中90天内mRS变化。
结果
在排除院内死亡病例后,在2344例患者中,共有583 (24.9%)例患者出院时获得良好的神经功能结果(mRS为0-2),1761 (75.1%)例患者出院时出现不良神经功能结果(mRS为3-5)。脑白质疏松程度加重(P for trend, 0.01)、严重(grade 4)脑萎缩(odds ratio, 2.02; 95% CI, 1.22-3.39, P=0.007)与出院时不良神经功能结果具有独立相关性。自出院后至脑卒中90天内平均(SD)mRS变化为0.57 (1.18)。脑白质疏松程度增加 (P for trend, 0.002)和严重脑萎缩(β [SE], -0.23 [0.115]; P=0.045)与自出院后至脑卒中90天内mRS改善较差具有相关性。
结论
本研究表明,对于颅内出血的幸存患者来说,脑出血是的脑小血管程度与出院时不良神经功能结果和自出院后至脑卒中90天内mRS改善较差具有相关性。

原始出处:
Uniken Venema SM, Marini S, Lena UK, et al,Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage.Stroke. 2019.DOI: 10.1161/STROKEAHA.119.025061
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    2020-03-03 mnda