CLIN CANCER RES:瘤内注射DC细胞可以改善肿瘤患者预后

2018-08-28 MedSci MedSci原创

树突状细胞(DC)通过抗原呈递激活继发免疫反应。临床前研究表明,瘤内注射活化DCs(aDCs;DCVax-Direct)的抑瘤效果优于不成熟DCs。CLIN CANCER RES近期发表了一篇文章,报道了瘤内注射aDCs治疗肿瘤临床试验的结果。

树突状细胞(DC)通过抗原呈递激活继发免疫反应。临床前研究表明,瘤内注射活化DCs(aDCs;DCVax-Direct)的抑瘤效果优于不成熟DCs。CLIN CANCER RES近期发表了一篇文章,报道了瘤内注射aDCs治疗肿瘤临床试验的结果。

该试验主要评估瘤内注射aDCs治疗实体肿瘤患者的安全性和有效性。使用标准的3+3设计,共3个剂量水平(每次注射aDCs2百万,6百万和一千五百万)。评估该疗法的可行性,免疫原性,注射后肿瘤微环境的改变情况以及患者生存情况。作者还研究了aDCs注射前细胞因子分泌情况。共入组40例患者, 其中39例可进行评估。瘤内注射aDCs耐受性良好,无剂量限制毒性。54%的患者中观察到淋巴细胞浸润增加。第8周病情稳定与总生存改善有关。aDCs分泌的IL-8和IL12p40增加与预后显着相关。分泌TNFα水平升高与第8周病情稳定正相关。

文章最后认为,瘤内aDCs注射安全可行。特定的细胞因子分泌增加与病情稳定和生存改善有关,因此注射前aDCs的功能与患者结局之前存在联系。

原始出处:
Vivek Subbiah,Ravi Murthy,et al.Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers.CLIN CANCER RES.August 2018 doi:10.1158/1078-0432.CCR-17-2707

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    2018-11-15 13718711b3m

    非常不错的学习资料,值得借鉴的临床经验,学习了,获益匪浅,感谢分享!

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    2018-10-22 13718711b3m

    学习了,涨知识,非常不错的临床经验,值得借鉴,受益匪浅,感谢分享!

    0

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    2018-08-30 明月清辉

    谢谢分享,学习了

    0

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    2018-08-29 kafei

    学习了谢谢

    0

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间皮瘤被认为是一种无免疫原性的肿瘤,对靶向PD-1/PD-L1治疗反应率也很低。之前的研究报道了自体肿瘤裂解物冲击DC的免疫治疗可以增加靶向恶性间皮瘤的T细胞反应。但是,使用自体肿瘤材料限制了大规模临床试验的进行。CLIN CANCER RES近期发表了一篇文章,研究异体裂解物冲击DC的免疫治疗的有效性及在人体内的安全性。

CLIN CANCER RES:肺癌瘤内注射CCL21基因修饰的DC细胞可以诱导肿瘤特异性免疫反应及CD8+T细胞浸润

CLIN CANCER RES近期发表一篇文章,评估了瘤内局部注射肿瘤疫苗的安全性及肿瘤抗原特异性免疫反应。晚期非小细胞肺癌(NSCLC)患者接受瘤内注射转载了表达CCL21基因腺病毒载体的自体DC细胞(Ad-CCL21-DC)。