JCC:阿片类药物使用紊乱增加了炎症性肠病患者的30天再入院风险

2020-06-28 MedSci原创 MedSci原创

近年来,随着对阿片类药物的使用不断增加,尤其是在患有慢性疼痛的炎性肠病[IBD]患者中,阿片类药物的流行已引起越来越多的关注。

背景和目标

近年来,随着对阿片类药物的使用不断增加,尤其是在患有慢性疼痛的炎性肠病[IBD]患者中,阿片类药物的流行已引起越来越多的关注。本项研究的目的是探究与IBD相关的住院后30天内再次出现阿片类药物使用障碍[OUD]的影响。

 

方法

研究人员回顾了国家再入院数据库(2010-2014年)中与IBD相关的成人住院和30天任何原因的再入院情况。计算了OUD和30天的再入院趋势。在住院期间未进行手术的患者中进行了常规且完全匹配的[EM] logistic回归和事件发生时间分析,以评估OUD对30天再入院风险的影响。

 

结果

本项研究的再入院总共鉴定出487728例:记录了UUD的有6633例[1.4%],有克罗恩病的有308845例[63.3%]。平均年龄为44.8±0.1岁,女性为54.3%。总体而言,30天再入院率为19.4%[ n = 94,546],在OUD患者中更高[32.6%VS 19.2%;p <0.001]。OUD案件增加了[1.1%至1.7%;p趋势<0.001],而30天的再入院率稳定[ p= 0.191]。在事件发生时间EM分析中,OUD患者被重新接纳的可能性增加47%(危险比1.47; 95%置信区间[CI]:1.28-1.69;p <0.001),平均更早被重新接纳32%[时间比0.68; 95%CI:0.59–0.78;p <0.001]。

 

结论

从2010年到2014年,住院IBD患者的OUD患病率一直在上升。平均而言,五分之一的患者会在30天之内再次入院。OUD与IBD患者30天再入院风险增加显着相关。

原始出处:

Paris Charilaou. Et al. Opioid Use Disorder Increases 30-Day Readmission Risk in Inflammatory Bowel Disease Hospitalizations: a Nationwide Matched Analysis. Journal of Crohn's and Colitis.2020.

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    2020-08-12 smlt2008
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    2020-06-30 lhlxtx
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