Clin Gastroenterology H: 健康的生活方式与炎症性肠病患者的死亡率降低相关

2021-01-02 MedSci原创 MedSci原创

健康生活方式不光能够给我们带来强健的体魄,还能够缓解某些疾病带来的恶性影响。目前尚不清楚健康的生活方式是否会影响包括克罗恩病(CD)和溃疡性结肠炎(UC)在内。

      健康生活方式不光能够给我们带来强健的体魄,还能够缓解某些疾病带来的恶性影响。目前尚不清楚健康的生活方式是否会影响包括克罗恩病(CD)和溃疡性结肠炎(UC)在内的炎症性肠病(IBD)患者的死亡率。因此,本项研究旨在对这方面进行相关研究。

 

      本项研究的数据是从美国“护士健康研究(1986-2014)”,“护士健康研究II(1991-2015)”和“卫生专业人员跟进研究”(1986-2014)的队列中筛选出来的,这些数据通过一系列问卷调查来评估生活方式。研究人员估计了IBD诊断后5种健康的生活方式因素和个体差异(从不吸烟,体重指数18.5-24.9 kg/m2,运动达最高强度的50%,地中海饮食评分≥4)与死亡率(使用Cox比例风险模型)之间的关系。

 

      本项研究在4741人年的随访期间共观察到363例CD患者中83例死亡,在6061人年随访期间观察到465例UC患者中80例死亡。IBD诊断的中位年龄为55岁。与没有健康生活方式因素的IBD患者相比,具有3-5种健康生活方式因素的IBD患者的全因死亡率显着降低(危险比[HR],0.29; 95%CI,0.16-0.52; P < .0001)。在单独危险因素分析中,超过25包香烟/年的患者死亡率更高(HR,1.92; 95%CI,1.24–2.97; P<.0001),体力活动是降低死亡率的保护性因素(HR,0.55–0.31; P = .001),地中海饮食也是降低死亡率的保护性因素(HR,0.69; 95%CI,0.49–0.98),当调整了IBD的家族史,免疫调节剂的使用情况以及与IBD相关的手术后,这些发现并没有改变。

 

 

      因此,在文章的结尾研究人员说道,在对来自3个大型队列研究的数据进行的分析中,研究人员更加坚定的认为坚持健康的生活方式与CD或UC患者的死亡率降低相关联。

 

 

原始出处:

Chun-Han Lo. Et al. Healthy Lifestyle Is Associated With Reduced Mortality in Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology Hepatology. 2021.

 

 

 

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    2021-11-08 许安
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    2021-01-02 ms2000001051330459

    学习了,涨知识了!

    0

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    2021-01-02 言西早

    健康生活方式不光能够给我们带来强健的体魄,还能够缓解某些疾病带来的恶性影响。

    0

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