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Biomater Sci：La掺杂介孔硅酸钙/壳聚糖支架可有效用于成骨

2019-02-01 MedSci MedSci原创

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痕量稀土元素如镧（La）可有效调节骨组织的表现，然而其潜在的机制仍然未知。为了加速骨质疏松或其他代谢性疾病患者的骨缺损的修复，我们首先采用冷冻干燥技术制备了镧掺杂介孔硅酸钙/壳聚糖（La-MCS / CTS）支架。在冷冻干燥过程中，通过使用冰晶作为模板在La-MCS / CTS支架内产生三维大孔，并且将La-MCS纳米颗粒分布在大孔壁上。结果显示，分层多孔结构和生物相容性组分有助于大鼠骨髓间充质干

痕量稀土元素如镧（La）可有效调节骨组织的表现，然而其潜在的机制仍然未知。

为了加速骨质疏松或其他代谢性疾病患者的骨缺损的修复，我们首先采用冷冻干燥技术制备了镧掺杂介孔硅酸钙/壳聚糖（La-MCS / CTS）支架。在冷冻干燥过程中，通过使用冰晶作为模板在La-MCS / CTS支架内产生三维大孔，并且将La-MCS纳米颗粒分布在大孔壁上。

结果显示，分层多孔结构和生物相容性组分有助于大鼠骨髓间充质干细胞（rBMSCs）的粘附、扩散和增殖，并加速新骨组织的内生长。特别地，骨支架中的La3 +离子通过TGF信号通路的激活明显诱导rBMSC的成骨分化。临界尺寸的颅骨缺损大鼠模型进一步揭示，与纯MCS/CTS支架相比，La-MCS / CTS支架显著促进了新的骨再生。

总之，La-MCS/CTS支架显示出突出的骨生成和骨再生能力，这表明其在骨缺损治疗中具有应用潜力。

原始出处：

Peng XY, Hu M, et al., La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering. Biomater Sci. 2019 Jan 28. doi: 10.1039/c8bm01498a.

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    2019-07-03 sunylz

    #Bio#

    0

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    2019-11-08 szhvet

    #硅酸钙#

    0

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    2019-08-17 luckyshitiancai_42705692

    #介孔#

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    2019-02-03 zhaojie88

    #成骨#

    0

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    2019-02-03 dlwang_26703132

    #壳聚糖#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1918509, encodeId=476419185092e, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jul 03 13:13:00 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705297, encodeId=67041e052974c, content=<a href='/topic/show?id=4394e351421' target=_blank style='color:#2F92EE;'>#硅酸钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73514, encryptionId=4394e351421, topicName=硅酸钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=933b30968945, createdName=szhvet, createdTime=Fri Nov 08 10:13:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664841, encodeId=7d09166484110, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Sat Aug 17 04:13:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351994, encodeId=e4bf1351994e9, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 03 14:13:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582426, encodeId=32e815824260e, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Sun Feb 03 14:13:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359773, encodeId=a455359e7371, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/02/02/6b6a1841a3d44664f3214b9822df4443.jpg, createdBy=0b351736074, createdName=1defb84dm30(暂无匿称), createdTime=Sat Feb 02 00:26:54 CST 2019, time=2019-02-02, status=1, ipAttribution=)]
    2019-02-02 1defb84dm30(暂无匿称)

    学习了

    0