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ACS Appl Mater Interfaces：研究人员成功研发了肿瘤微环境pH值下可重组的肽纳米材料

2017-09-19 MedSci MedSci原创

肽纳米材料肿瘤微环境PH
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肽纳米材料近年来引起了生物医学界的极大兴趣，但生物利用度低，治疗效果差，阻碍了其进一步的应用。 本研究中，研究人员制备了在肿瘤微环境中可重构和激活的纳米疗法。研究人员将两种肽，即具有聚合（乙二醇）（PEG）末端的pH响应肽HLAH和基质金属蛋白酶-2（MMP2）-敏感肽与疏水性聚（β-硫酯）骨架耦合以获得共聚物P-S-H。由于其重置是在肿瘤微环境pH中，因此HLAH肽的治疗活性可在肿瘤中被激

肽纳米材料近年来引起了生物医学界的极大兴趣，但生物利用度低，治疗效果差，阻碍了其进一步的应用。

本研究中，研究人员制备了在肿瘤微环境中可重构和激活的纳米疗法。研究人员将两种肽，即具有聚合（乙二醇）（PEG）末端的pH响应肽HLAH和基质金属蛋白酶-2（MMP2）-敏感肽与疏水性聚（β-硫酯）骨架耦合以获得共聚物P-S-H。由于其重置是在肿瘤微环境pH中，因此HLAH肽的治疗活性可在肿瘤中被激活。

所制备的共聚物在生理条件下自组装成纳米颗粒，核心为HLAH，壳为PEG。中等大小（〜100nm）和负电位保证了血液中P-S-H的稳定循环。一旦到达肿瘤部位，P-S-H纳米颗粒便会被过表达的MMP2和酸性pH刺激，随后PEG壳脱落，HLAH肽质子化诱导纳米颗粒重组，导致纳米颗粒表面活化细胞毒性肽的形成。

体内实验表明，重组纳米颗粒有三个优点：（1）肿瘤部位有效积累，（2）提高抗肿瘤能力，（3）治疗剂量无明显毒性作用。这种靶点重组策略为在癌症治疗中开发高性能肽纳米材料提供了新的途径。

原始出处：

Zeng-Ying Qiao, Wen-Jing Zhao, et al., Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH. ACS Appl. Mater. Interfaces, 2017, 9 (36), pp 30426–30436.

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    2017-09-25 gostraight

    #研究人员#

    0

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    2018-04-30 夏天与十三菇凉

    #FAC#

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    2018-01-15 shanyongle

    #ACE#

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    2017-09-21 yaanren

    #ACS#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1907509, encodeId=feb2190e509ba, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Sep 25 14:36:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956654, encodeId=3d0c19566544e, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Apr 30 02:36:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655794, encodeId=324c1655e9427, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Mon Jan 15 02:36:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279186, encodeId=1a1212e9186e2, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1300064, encodeId=df781300064fc, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479476, encodeId=585114e94761b, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245885, encodeId=0553245885d1, content=学了666, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Sep 20 07:01:23 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-21 lqvr

    #研发#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1907509, encodeId=feb2190e509ba, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Sep 25 14:36:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956654, encodeId=3d0c19566544e, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Apr 30 02:36:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655794, encodeId=324c1655e9427, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Mon Jan 15 02:36:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279186, encodeId=1a1212e9186e2, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1300064, encodeId=df781300064fc, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479476, encodeId=585114e94761b, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245885, encodeId=0553245885d1, content=学了666, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Sep 20 07:01:23 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-21 12498710m13暂无昵称

    #纳米材料#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1907509, encodeId=feb2190e509ba, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Mon Sep 25 14:36:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956654, encodeId=3d0c19566544e, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Apr 30 02:36:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655794, encodeId=324c1655e9427, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Mon Jan 15 02:36:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279186, encodeId=1a1212e9186e2, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1300064, encodeId=df781300064fc, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479476, encodeId=585114e94761b, content=<a href='/topic/show?id=1e30e739295' target=_blank style='color:#2F92EE;'>#纳米材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77392, encryptionId=1e30e739295, topicName=纳米材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cde87531954, createdName=12498710m13暂无昵称, createdTime=Thu Sep 21 10:36:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245885, encodeId=0553245885d1, content=学了666, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Sep 20 07:01:23 CST 2017, time=2017-09-20, status=1, ipAttribution=)]
    2017-09-20 哈哈869

    学了666

    0