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Sci Rep：基于LC-MS的肾细胞肿瘤组织学亚型代谢组学分析

2019-11-14 AlexYang MedSci原创

肾细胞肿瘤代谢组学分析治疗策略
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肾细胞肿瘤（RCC）是根据他们的组织学特性进行分类的。RCC准确的分类和代谢异常的综合理解具有非常重要的意义。最近，有研究人员调查了使用代谢组学分析对主要的RCC亚型进行分类情况，并描述了每一种亚型的代谢变异情况。研究人员使用液相色谱-质谱法对65个RCC冷冻样本进行了代谢组学分析（40个透明细胞癌，14个乳头状癌和11个嫌色性细胞癌）。基于代谢组数据的OPLS-DA多变量分析表明了3种RCC主要

肾细胞肿瘤（RCC）是根据他们的组织学特性进行分类的。RCC准确的分类和代谢异常的综合理解具有非常重要的意义。

最近，有研究人员调查了使用代谢组学分析对主要的RCC亚型进行分类情况，并描述了每一种亚型的代谢变异情况。研究人员使用液相色谱-质谱法对65个RCC冷冻样本进行了代谢组学分析（40个透明细胞癌，14个乳头状癌和11个嫌色性细胞癌）。基于代谢组数据的OPLS-DA多变量分析表明了3种RCC主要亚型明显的区别（R2=75.0%， Q2=59.7%）。研究人员通过一个独立的群体对预后表现进行了评估，透明细胞癌，乳头状细胞癌和嫌色性细胞癌的AUROC分别为0.924， 0.991和1。21种顶级代谢物的进一步途径分析表明氨基酸和脂肪酸代谢在3种RCC亚型之间存在显著差异。

最后，研究人员指出，他们的研究表明了代谢组情况可以作为RCC组织学亚型分析的一种补充工具。另外，研究人员确立了RCC亚型中的代谢异常总的情况，对于临床行为的理解以及靶向治疗策略的开发提供了新的认知。

原始出处：

Lun Jing， Jean-Marie Guigonis， Delphine Borchiellini et al. LC-MS based metabolomic profiling for renal cell carcinoma histologic subtypes. Sci Rep. 30 Oct 2019

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    2020-08-20 isabellayj

    #肾细胞肿瘤#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1680030, encodeId=67b5168003082, content=<a href='/topic/show?id=ab358265095' target=_blank style='color:#2F92EE;'>#肾细胞肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82650, encryptionId=ab358265095, topicName=肾细胞肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19d27833533, createdName=isabellayj, createdTime=Thu Aug 20 08:45:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926264, encodeId=4a1e192626447, content=<a href='/topic/show?id=9238e767680' target=_blank style='color:#2F92EE;'>#组织学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77676, encryptionId=9238e767680, topicName=组织学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Mon Apr 13 03:45:00 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480302, encodeId=a497148030258, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Sat Nov 16 12:45:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375230, encodeId=e62a3e52307d, content=学习了，不错的话题，非常精彩，受益非浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b005228115, createdName=14794e5bm67(暂无昵称), createdTime=Fri Nov 15 18:02:47 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050714, encodeId=5ba11050e1406, content=代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Fri Nov 15 00:45:00 CST 2019, time=2019-11-15, status=1, ipAttribution=)]
    2020-04-13 bnurmamat

    #组织学#

    0

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    2019-11-16 ms6897892027066920

    #代谢组#

    0

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    2019-11-15 14794e5bm67(暂无昵称)

    学习了，不错的话题，非常精彩，受益非浅

    0

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    2019-11-15 明天jing

    代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。

    0

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