Prostate Cancer P D :积极监控群体中的前列腺癌与MRI

2018-08-04 AlexYang MedSci原创

多参数核磁共振成像(mpMRI)在前列腺癌的积极监测(AS)中使用越来越多。最近,有研究人员调查了关于AS的病灶mpMRI表现的变化,来表明可视病灶体积测量的可变性,从而跟君等级评估病灶大小的变化情况。研究人员回顾性的检索了86名AS的男性,并且经历了不少于1次mpMRI(第一次在2013年前)。2名放射科专家均对患者参数和扫描时间处于不知状态。他们对扫描进行随机的报告来减少偏差。对可视的病灶,研

多参数核磁共振成像(mpMRI)在前列腺癌的积极监测(AS)中使用越来越多。最近,有研究人员调查了关于AS的病灶mpMRI表现的变化,来表明可视病灶体积测量的可变性,从而跟君等级评估病灶大小的变化情况。

研究人员回顾性的检索了86名AS的男性,并且经历了不少于1次mpMRI(第一次在2013年前)。2名放射科专家均对患者参数和扫描时间处于不知状态。他们对扫描进行随机的报告来减少偏差。对可视的病灶,研究人员通过平面几何来测量体积。研究发现,43/86名男性在首次mpMRI(≤2/5)中没有可视的病灶,其中5/43名在平均3.6年的跟踪调查中发展为病灶评分 ≥3/5。40/86名在2次或者更多的扫描中病灶评分≥3/5。在3.6年的跟踪调查期间,病灶的体积有显著的增加,增加的幅度均值为10%(p<0.01),其中格林森3+3增加均值为6%,3+4增加均值为18%(p=0.058)。另外,在2年内分别进行的2次扫描中,35名男性具有可视的病灶,其中,21/35表现出了2次扫描肿瘤体积78%的增长,11/35表现出了病灶大小25%的减少。

最后,研究人员指出,在平均3.6年的跟踪调查期间,总共有17%没有可视病灶的男性发展成为具有可视病灶。研究人员还指出,在具有可视病灶的患者中展现其显著的增长是可能的,但是在不同扫描中体积测量的可变性意味着可靠的检测其体积的增加是困难的。上述可变性可能与AS中mpMRI方法的设计和跟踪调查扫描时间间隔有关。

原始出处:

Francesco Giganti, Caroline M. Moore, Shonit Punwani et al. The natural history of prostate cancer on MRI: lessons from an active surveillance cohort. Prostate Cancer P D . 23 July 2018.

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    2018-11-20 xjy13
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  3. [GetPortalCommentsPageByObjectIdResponse(id=1716988, encodeId=396a1e169884c, content=<a href='/topic/show?id=f8a98002eb1' target=_blank style='color:#2F92EE;'>#群体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80027, encryptionId=f8a98002eb1, topicName=群体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c0832353243, createdName=xjy13, createdTime=Tue Nov 20 05:39:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791542, encodeId=81f31e91542fa, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun Jan 20 19:39:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337834, encodeId=7b1d33e83463, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Aug 11 07:19:47 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364363, encodeId=291e13643635a, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602040, encodeId=846a16020401b, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617676, encodeId=e989161e67668, content=<a href='/topic/show?id=6287e512359' target=_blank style='color:#2F92EE;'>#积极监控#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75123, encryptionId=6287e512359, topicName=积极监控)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc019794125, createdName=ms5106640509429053, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336613, encodeId=cbdb3366139c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Aug 05 11:43:36 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-11 Jackie Li

    学习

    0

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    2018-08-06 lsndxfj
  5. [GetPortalCommentsPageByObjectIdResponse(id=1716988, encodeId=396a1e169884c, content=<a href='/topic/show?id=f8a98002eb1' target=_blank style='color:#2F92EE;'>#群体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80027, encryptionId=f8a98002eb1, topicName=群体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c0832353243, createdName=xjy13, createdTime=Tue Nov 20 05:39:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791542, encodeId=81f31e91542fa, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun Jan 20 19:39:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337834, encodeId=7b1d33e83463, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Aug 11 07:19:47 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364363, encodeId=291e13643635a, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602040, encodeId=846a16020401b, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617676, encodeId=e989161e67668, content=<a href='/topic/show?id=6287e512359' target=_blank style='color:#2F92EE;'>#积极监控#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75123, encryptionId=6287e512359, topicName=积极监控)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc019794125, createdName=ms5106640509429053, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336613, encodeId=cbdb3366139c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Aug 05 11:43:36 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-06 sunylz
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1716988, encodeId=396a1e169884c, content=<a href='/topic/show?id=f8a98002eb1' target=_blank style='color:#2F92EE;'>#群体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80027, encryptionId=f8a98002eb1, topicName=群体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c0832353243, createdName=xjy13, createdTime=Tue Nov 20 05:39:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791542, encodeId=81f31e91542fa, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun Jan 20 19:39:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337834, encodeId=7b1d33e83463, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Aug 11 07:19:47 CST 2018, time=2018-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364363, encodeId=291e13643635a, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602040, encodeId=846a16020401b, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617676, encodeId=e989161e67668, content=<a href='/topic/show?id=6287e512359' target=_blank style='color:#2F92EE;'>#积极监控#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75123, encryptionId=6287e512359, topicName=积极监控)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc019794125, createdName=ms5106640509429053, createdTime=Mon Aug 06 02:39:00 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336613, encodeId=cbdb3366139c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Aug 05 11:43:36 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 一个字-牛

    学习了谢谢分享

    0

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