Heart:骨密度对女性不良心血管疾病的预后价值如何?

2021-05-08 MedSci原创 MedSci原创

女性BMD评估可为ASCVD事件提供了独立且额外预后价值,因此可以改善女性的风险分层。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在调查评估骨密度(BMD)是否可为女性动脉粥样硬化性血管疾病(ASCVD)的预测提供了独立且额外的预后价值。

研究人员回顾性地分析了12681名年龄在50-80岁(平均63.0±7.8岁)且接受了双能X射线吸收测定的妇女。

根据BMD或骨质减少或骨质疏松的临床诊断评估了ASCVD事件(ASCVD死亡、非致命性心肌梗塞和缺血性卒中)的风险比(HR),并调整了临床危险因素,包括年龄、体重指数、,高血压、2型糖尿病、高脂血症、当前吸烟和既往骨折。研究人员还评估了在临床危险因素中添加BMD或骨质减少或骨质疏松症的临床诊断是否能改善对ASCVD事件的预测效能。

骨密度对ASCVD的预测价值

该研究总共有468名(3.7%)女性在随访期间(中位数为9.2年)经历过ASCVD事件。腰椎、股骨颈和全髋关节的BMD降低与较高的ASCVD事件风险独立相关(BMD每降低1个标准差调整后的HR分别为1.16,p<0.001; 1.29,p<0.001; 1.38,p<0.001)。骨质疏松症也与较高的ASCVD事件风险相关(调整后的HR:1.79,p<0.001)。在临床危险因素中添加BMD或骨质减少或骨质疏松症临床诊断可额外增加ASCVD事件的识别效能(p<0.001)。

由此可见,女性BMD评估可为ASCVD事件提供了独立且额外预后价值,因此可以改善女性的风险分层

原始出处:

Jiesuck Park.et al.Prognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women.heart.2021.https://heart.bmj.com/content/early/2021/04/01/heartjnl-2020-318764

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    2021-05-10 1881ef655dm

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    2021-05-10 zhaojie88
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    2021-05-10 slcumt
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    2021-05-08 ms6000001624652641

    学习

    0

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50岁以上男性,睾丸激素治疗2年主要是通过影响皮层骨,使骨密度增加。降低骨折风险的意义需要进一步研究。

JCEM:胰岛素样生长因子-1、骨密度和骨折的关系

该研究的结果支持IGF-1对骨折具有预防作用,可能并部分是由更高的骨密度所介导。

Metabolism:老年男性睾酮、双氢睾酮与骨密度和髋部骨折风险的关系

在老年男性中,DHT与髋部骨折风险呈负相关,而SHBG与髋部骨折风险呈正相关,而T与年龄无关。未来的研究应阐明DHT影响骨骼健康的机制。

Brit J Cancer:接受阿那曲唑治疗5年的绝经后妇女骨密度变化

这是第一个报告停止阿那曲唑预防乳腺癌患者中BMD变化的研究。该研究的结果表明,阿那曲唑用于预防乳腺癌对BMD的负面影响部分是可逆的。

Arch Osteoporos:脊柱旁肌肉的脂肪浸润与腰椎骨质密度有关

本研究旨在探讨腰椎旁肌肉脂肪浸润与腰椎骨质密度(BMD)的关系,研究结果已在线发表于Arch Osteoporos。